Expression Of Glucocorticoid Receptor In The Femoral Cartilage And Coxa Synovial Membrane Of Perthes Disease

Objective:To examine the expression of glucocorticoid receptor(GR) in the femoral head cartilage and coxa synovial membrane of Perthes disease,and to explore the relationship between glucocorticoid receptor and Perthes disease.Methods:Twenty specimens of the femoral head cartilage and coxa synovial membrane were obtained by surgery.These specimens were sended from twenty patients with perthes disease admitted to Zunyi Medical college affiliated hospital from December 2006 to May 2008.Ten specimens as control group were involved in this study.There were 3 specimens from hip disarticulation and 7 specimens from children corpse.Immuno-histochemistry and image analysis were employed to detect the expression of GR in these specimens. Expression of glucocorticoid receptor was compared between Perthes disease group and the control group.Results:1.GR were expressed in all 20 cases of Perthes disease femoral head cartilage.In the control group,GR were expressed in only one case.The difference of GR expression of the femoral head cartilage between the Perthes disease group and the control group was significant (P＜0.01).GR were expressed in all 20 cases of Perthes disease coxa synovial membrane.In the control group,GR were expressed in 2 cases.The difference of GR expression of the coxa synovial membrane between the Perthes disease group and the control group was significant(P＜0.01).2.GR intergrated optical density(IOD) of the femoral head cartilage in the Perthes disease group was compared with the control group,the difference was significant(t=5.893, P＜0.01).GR IOD of the coxa synovial membrane in the Perthes disease group was compared with control group,the difference was significant(t=11.720,P＜0.01).3.Coefficient correlation of GR of the femoral head cartilage to the coxa synovial membrane in Perthes disease was 0.787(P＜0.01),positive.Conclusion:GR might play an important role in the growth and development of the pathogenesis of Perthes disease.The linking of GR and GC might promote occurrence and development of Perthes disease.