Study On The Traditional Chinese Medicine Types Syndrome Of Chronic Hepatitis B

Objective: To collect clinical cases and laboratory test results, it are observed the relationship of chronic hepatitis B-type of TCM prescriptions and laboratory tests, the basic structure, and are explored relations and differences of evidence-based clinical and laboratory examination, the heart of drugs, drug categories and drugs mutual.Methods: To collect April 2008-March 2009 University Affiliated Hospital Infection Section, digestion out-patient clinics and wards for 300 cases of diagnosed chronic hepatitis B patients with clinical data, including a brief medical history, symptoms, syndrome type, laboratory inspection (such as liver function, HBV-DNA quantification Ganxian three) and herbs such as effective data, the database is set up. statistical software SPSS13.0 and Access are used to analy all data, measurement data in line with the normal distribution is used t tests (between group homogeneity of variance test to 0.05 as the standard test, variance missing, the correction to the t test), to not meet normal distribution with Friedman rank sum test; chi-square test is used count data.Results: The TCM syndrome distribution results showed that: the majority of liver stagnation and spleen deficiency, heat resistance of network card and the card by obstructing blood are followed, liver and spleen of Kidney-Yang Deficiency Kidney Yin Deficiency is rare. Damp-heat in liver and gallbladder are more concentrated in chronic hepatitis B patients with moderate and severe, stagnation of liver-type spleen is tended to be concentrated in patients with mild chronic hepatitis B, and obstructing network congestion and kidney-yin deficiency of liver-type in chronic hepatitis B are accounted for moderate and severe a larger proportion. TCM and the detection of liver function of the results of the comparison showed that: (1) patients with heat resistance of the ALT, AST was significantly higher than the mean results of the other 4, however, evidence-based comparison between the eachother is non-differences (P> 0.05). (2) TBil, DBil abnormal value are mainly in heat resistance of type, the mean was significantly higher than the other 4, however, evidence-based comparison between the eachother and was no difference (P> 0.05). (3)TCM syndrome virus replication in the results of the comparison showed that : liver stagnation and spleen deficiency in patients with active viral replication (P> 0.05); and the liver and gallbladder damp-heat stage of virus replication at a low (P> 0.05). Liver stagnation and spleen deficiency with high virus replication associated with more status. HBeAg-positive rate at Deficiency in high disease but is at low inclination, but the card-type room is no difference. Bupleurum, Scutellaria, Atractylodes macrocephala, Glycyrrhiza, Radix Paeoniae Rubra, Radix, sarmentosum, are eight former Yinchen medication. " reinforce asthenia medicine, Qingre medicine, excreting dampness Diuresis drug, huoxuehuayu medicine, medicine qi" It is composed of five drugs to the heart of chronic hepatitis B-type, and is closely related to evidence-based medicine to the highest frequency of occurrence, such as liver stagnation and spleen deficiency of Chaihu - Atractylodes macrocephala; Jiao Damp-heat in the capillaries - kwangsiensis, capillaris - Reynoutria; liver kidney-yin deficiency and evidence of Chinese wolfberry - habitat; network cards stop blood Salviae -Chishao; Qi stagnation blood stasis syndrome of Chaihu - Chishao.Conclusion: The chronic hepatitis B in patients with liver stagnation and spleen deficiency is the most common, stagnation of liver deficiency, heat in the resistance, resistance network congestion, kidney-yin deficiency of liver, spleen kidney yang deficiency is the development of chronic viral hepatitis B process different phase, but the relevance of different type and physical and chemical evidence is different indicators. Medication should be noted that (1) attention to a combination of function such as Huoxue, Qingre (detoxification), dampness Qi, reinforce asthenia structure; (2) attention to blood circulation and clearing away heat and toxic; (3) re-emphasize reinforce qi and circulation qi particular reinforce asthenia; (4) liver and spleen and kidney weight of liver and spleen cohomology.