Effect Of Short-term CSâ…¡ Intensive Therapy On The Level Of GLP-1 In Newly Diagnosed Type 2 Diabetes

Objective To observe the effect of short-term intensive insulin therapy (short-term Continues the subcutaneous insulin infusion,CSâ…¡) on the level of GLP-1 in the new diagnosed type 2 DM patients,and then to explore the possible mechanics..Methods 21 Newly diagnosed type 2 DM patients received CSâ…¡therapy for 14 days.Before and after intensive insulin therapy,the blood was drawn on OGTT test(0min,30min,120min),then the levels of fasting and post-prandial plasma glucose,insulin,C-peptide and GLP-1 were tested.17 Non-diabetic subjects were also tested glucose,insulin,C-peptide and GLP-1 during OGTT test(0min,30min, 120min) as control..Homa-IR,Homa-IS,AUCg(area under blood glucose curve), AUCins(area under insulin curve),AUCc(area under C peptide curve), AUCglp-1(area under GLP-1 curve),â–³INS₃₀/â–³G₃₀ andâ–³INS₁₂₀/â–³G₁₂₀ of each group were calculated due to glucose,insulin,C-peptide,GLP-1.Results Glucose was increased and insulin C peptide,GLP-1 were decreased in DM group compared with control;After intense insulin therapy,the glucose and AUCg were significant decreased,AUCins,AUCc increased,HOMA-IR decreased while HOMA-IS,â–³INS₃₀/â–³G₃₀ andâ–³INS₁₂₀/â–³G₁₂₀ increased(P＜0.05);After intensive insulin therapy,GLP-1 levels were higher then before treatment(P＜0.05); There was a negative correlation between AUCglp and the time when blood glucose been controlled.After therapy,there also had a negative correlation between AUCglp and Homa-IR.Conclusion GLP-1 was decreased in new diagnosed type 2 DM patients. Short-term intensive insulin therapy can increase the level of GLP-1,the reason maybe intensive insulin therapy can improve the function ofβ-cell,ameliorate Homa-IR..