| Objective:To look into the differentce of blood plasma lysophosphatidic acid(LPA) and P-selection(CD62p) between healthy grown-up and blood stasis ?acute cerebral thrombosis,at the same time,observe the change of blood plasma LPA and CD62p of different acute cerebral thrombosis area,different blood stasis degrees,different Neurological Severity Score(NSS)。To observe the levels of blood plasma LPA,D62p and NSS,blood stasis degree effected by danshen chuanxionqin injection,and further explain the possible mechanism of danshen chuanxionqin injection。Methods:60 patients with blood stasis ´ cerebral thrombosis in hospital no more than 72 hours were randomly divided into group B1(routine treatment group) and group B2(dansh chuanxiongqin injection treatment group).30 cases(male20,female10,mean age 63.87±11.35) were served as B1,30 cases(malel9,female11,mean age 63.43±11.25) were served as B2.30 normal cases(malel8,female12,mean age 64.20±10.47 ) were served as group A(normal contrast group).Routine western medicine(including dehydration and degrading intracranial pressure,controling blood pressure,resisting platelet aggregation and degrading fibrinogen etc.) were given to 30patients of group Bl,and danshen chuanxiongqin injection was given to another 30patients of group B2 in addition.Vein blood samples were collected before breakfast in the second day and the fourteenth day after take into the hospital.Both LPA,CD62p were tested by ELISA.And then analysis the connection between the value of LPA,CD62p and NSS,blood stasis degree,and further explain the influence of danshen chuanxionqin injection to LPA,CD62p。Results:1.The levels of blood plasma LPA,CD62p of group B(the cases with acute cerebral thrombosis) were markedly higher than those in group A(P＜0.01),the difference between group Bl and B2 is insignificant(P＞0.05).2.The higher blood stasis degree,the levels of LPA,CD62p are higher.,the difference among the three groups are significant(P＜0.05).3.The larger area of acute cerebral thrombosis,the levels of LPA,CD62p are higher(P＜0.01),the difference among the three groups are significant(P＜0.05).4.The higher of NSS,the higher of LPA,CD62p(P＜0.05). 5.Group B2 surpasses group B1 obviously in neurologic impairment therapeutic effects(P＜0.05).6.After treatment,the levels of LPA,CD62p of groupB2 are much lower than group B1(P＜0.05).7.After treatment,the descend range of NSS is related to blood plasma LPA,CD62p(r=0.83, 0.53,P＜0.01)8.After treatment,the descend range of NSS is related to blood stasis(r=0.71,P＜0.01)Conclusions:1.The levels of ACTs' blood plasma LPA,CD62p are obviously higher than healthy grown up,at the same time,the level of LPA,CD62p are correspondence with the area and the disease' conditions.2.The levels of blood plasma LJA,CD62p are correspondence with the degree of blood stasis,it could illuminated that the LPA,CD62p' level can reflect the blood plasma' degree, it could also illuminated that there is some relationship between the blood stasis' theory and modem gore theory.3.Danshen chuanxionqin injection can effectly affect the prognosis of the patients who suffering blood stasis＆acute cerebral thrombosis,the prognosis is respond to the level of LPA,CD62p,it could be explained that danshen chuanxiongqin injection could restrain blood platelet's activation,it could restrain blood platelet adhere to injured endothelium,reduce the pathology damage from inflammation after cerebral ischemia,reduce the cerebral edema and improve the blood circulation of partial brain. |
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