The Changes And Correlations Between Airway Inflammation And Systemic Inflammation Of Chronic Obstructive Pulmonary Disease

ObjectiveTo investigate the changes and correlations between airway inflammation and systemic inflammation during acute exacerbations of chronic obstructive pulmonary disease(AECOPD) and clinical stable state.MethodsBlood serum levels and induced sputum supernate fluid contents of IL - 8,TNF -a were measured with ELISA and CRP by nephelometry method in 45 patients with COPD both during exacerbation and remission. As well as lung function FEV1.0%Pred was examined in patients with COPD during acute exacerbation and remission.SPSS12.0 was used to perform statistics.Results1.After treatment,both the blood serum levels and induced sputum supernate fluid contents of IL - 8,TNF -a,CRP during remission were significantly lower than those in patients with COPD during exacerbation(all P＜0.01). 2.Both the blood serum levels and induced sputum supernate fluid contents of respectively IL - 8,TNF -a,CRP were negatively correlated with the FEV1.0%Pred in patients with COPD(all P＜0.05).3.The levels of IL -8,TNF -a were not correlated between in blood serum and in induced sputum supernate fluid(r=0.492,P＞0.05; r=0.412,P＞0.05),but CRP were closely correlated(r=0.864,P＜0.01).Conclusion1.Airway inflammation and systemic inflammation during exacerbation were obviously reinforced than during remission,and possibly aggravated air current obstruct of COPD.2.There were possibly different inflammatory pathways between airway inflammation and systemic inflammation.