The Relationship Between Clinical Serum Markers And Coronary In-stent Restenosis

Objective:To assess the relationship between serum markers and coronary in-stent restenosis after drug-eluting stent implantation.Method:The study enrolled 214 patients who underwent drug-eluting stent implantation and accept coronary angiography for recurrent chest pain or routine follow-up.A＞50%-diameter stenosis was used as a definition of restenosis.Multiple clinical data and risk factor of coronary heart disease were collected,and the clinical serum markers were detected.Results:Among the 214 patients(278 lesions),restenosis occurred in 90 patients(110 lesions).Compared to non-restenosis group,serum markers such as lipoprotein a, conjugated bilirubin,glutamic pyruvic transaminase,aspartate aminotransferase, cholinesterase and fibrinogen in restenosis group had no significant differences;indexes such as serum LDL/HDL,total bile acid,uric acid,alkaline phosphatase and glutaminoacytransferase level were higher and serum total bilirubin level was lower in restenosis group than non-restenosis group,all of which reached significant statistic difference(P＜0.05).As a result of multivariate regression analysis,diabetes(OR=1.038), high serum level of LDL/HDL(OR=1.542),total bile acid(OR=1.197),urine acid (OR=1.113) and long lesion(OR=1.331) were risk factors contributed to restenosis (P＜0.05),while high serum total bilirubin level(OR=0.891)was a protecting factor to restenosis.Conclutions:Clinical serum markers such as total bilirubin,total bile acid,urine acid,and LDL/HDL level are significantly correlated with in-stent restenosis after drug-eluting stent implantation in coronary artery.