A Case-control Study On The Risk Factors In Ulcerative Colitis

Aims: A case-control study was conducted to investigate the possible risk factors in the pathogenesis of Ulcerative Colitis (UC).Methods: A survey was employed. The questionnaire consisted of 32 items, including family history of IBD, smoking age, milk intake, work tension, alcohol intake, history of intestinal infection, appendectomy, and use of NSAID drugs, and so on. Logistic regression analysis was done to select statistically significant risk factors after the questionnaire was collected.Results: The study was based on 100 diagnosed patients with UC and 100 healthy people. Single factor analysis was carried out to identify the following possible related factors: work tension, household refrigerator, drinking milk, western fast food, smoking, breastfeeding, family history of IBD, history of intestinal infection, non-steroidal analgesic drugs, having suffered from measles or intestinal parasites. Multivariate logistic regression analysis was conducted thereafter to find out statistically significant risk factors: family history of IBD (OR=11.251), milk intake (OR=7.020), the history of intestinal infection (OR=5.063), intake of fried foods (OR=3.812), and smoking (OR=0.240).Among those factors, smoking was the protective factor.Conclusions: Family history of IBD, intake of fried foods, milk intake, infectious diarrhea are possible risk factors in the pathogenesis of UC; smoking might be the protective factor for UC.