| Objective: To explore the change of the erythrocyte membrane fluidity and to analysis the relevance between it and neonatal behavioral neurological assessment in neonates with hypoxic-ischemic encephalopathy. It can be used for providing the objective evidence in early diagnosis, evaluating the degree of brain damage and studing the pathogenesis of HIE .Method: we collected 60 HIE cases from the Children's Hospital of Shanxi Province from March 2008 to February 2009. The diagnosis is according to"The clinical diagnostic criteria and sub-degree of Neonatal HIE"which revised by the 2004 session ChangSha Conference. We measured the erythrocyte membrane fluidity of neonates with HIE at the age of 0-3 days and 14 days by the fluorescence polarization technique and took neonatal behavioral neurological assessment by professional physicians, and explored the relevance between them. We selected 20 full-term newborn as a control group which were no history of perinatal asphyxia, birth trauma, no intrauterine growth retardation and infectious, metabolic diseases, and except of nuclear jaundice and central nervous system malformation.They mother were health during pregnancy.Result: The membrane fluidity of erythrocyte and the NBNA in neonates with HIE were both significantly lower than that of control group at the acute stage(P<0.01);at the convalescence stage, both of them rises,but was still significantly lower than normal control group . And there were positive correlations between them at both acute and convalescence stage. The correlation coefficients were 0.572 and 0.57 respectively (P<0.001).Conclusion: Erythrocyte membrane fluidity changed in the process of the neonatal hypoxic-ischemic encephalopathy. Erythrocyte membrane fluidity in the acute phase and recovery phase with NBNA score was a positive correlation. Erythrocyte membrane fluidity can be used as early HIE evaluation indicators of the extent of brain injury and brain injury recovery. |
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