Dihuang Mixture (Capsule) In The Treatment Of Multiple Sclerosis In Acute Relapse Phase Of Clinical Research

Multiple sclerosis(MS) is a common inflammatory demyelination in the central nervous system as the main features of autoimmune diseases.Multiple sclerosis occur in young and middle-aged,often to ease the course of the recurrence of symptoms of nervous system damage.Studies suggest that the higher the latitude the higher prevalence rate of MS,so the northern and southern hemispheres.China is a low-incidence areas for MS,but with the awareness of MS,the current cases have been found more frequently.Through long-term clinical observations,that Professor Min Gao MS pathogenesis of Chinese medicine is based on Liver-kidney yin Deficiency of the internal resistance of phlegm and blood stasis,so self-made Dihuang mixture(Prepared radix rehmanniae,Cornus officinalis,Liriope,Cistanche,White peony root,Sweetflag, Arisaema cum bile,Geosaurus,Curcuma aromatica salisb,Muscardine silkworm) to nourish the liver and kidney,promoting blood circulation Tongluo clinical prevention and treatment for MS.In the pre-study,Dihuang mixture have significantly reduced cerebrospinal fluid mixture of CD4~+cells and CD8~+cells was significantly increased,thereby significantly reduced CD4~+/CD8~+ ratio,play a role in immune regulation.And in the prevention of relapse in multiple sclerosis clinical observation,the use of mixture Dihuang years after relapse in patients with MS significantly reduced the number,suggesting that mixture Dihuang MS can be effective in preventing relapse.After further study found that mixture Dihuang glial cells by inhibiting activation and reduce the central nervous system in MS patients with glial fibrillary acidic protein and acidic calcium-binding protein of the table again and again,the impact of MS and reduce the occurrence and development of the frequency of relapse in patients with MS.First of all clinical neurological rehabilitation clinical need appropriate, scientifically sound and reflect the views of scale in patients as a tool for patients and the assessment of the results achieved.Intuitive,the benefits of treatment interventions provide strong evidence of the basic point is the use of scientific and rational scale to assess.In MS the area,Kurtzke'S expanded disability scale score(EDSS) can be used to describe the majority of the functional status of patients with MS.Index classification scheme of daily life(Barthel index) Determination of activity of daily living is an effective way to compare the contents of a comprehensive,easy points,clear and can be sensitive to reflect changes in condition or function of the progress,for observation for efficacy and prognostic means.This research Dihuang mixture(capsule) in the treatment of acute relapsing multiple sclerosis before and after the period of Kurtzke'S expanded disability scale score(EDSS) and the daily life index(Barthel index) the impact of specific methods to period 60 cases of acute relapse in patients with MS,According to the method of randomly divided into treatment group(30 cases) and control group(30 cases),the treatment group given methylprednisolone,prednisone-based therapy plus conventional Western medicine Dihuang mixture(capsule),the control group Conventional Western medicine is to increase placebo treatment,three weeks into a course of treatment,the treatment of two courses of treatment.The results showed that the expansion of the two groups by the Kurtzke'S disability scale score(EDSS) assessment,treatment after three weeks the two groups was not significant,but the first score of the six weeks the two groups was statistically significant(P＜0.001).Index of daily life(Barthel Index) evaluation also showed that the first six weeks after treatment the score the two groups was statistically significant (P＜0.05).Two groups of patients on a one-year follow-up to observe the frequency of its recurrence,the two groups was statistically significant(P＜0.05).Conclusion:In acute stage of multiple sclerosis,the application of conventional Western medicine hormone treatment can quickly ease the patient's condition after six weeks in the application of additional land for Dihuang mixture(capsule) treatment for more significant clinical efficacy,clinical worthy of further promotion;At the same time,the combined use of Dihuang mixture(capsule) of the treatment group patients after the use of hormone-induced upset irritability,the five upset hot,insomnia,night sweats,The mouth swallows dry does symptoms,such as the number of cases less compared with the control group,the two group were significantly different(P＜0.05).