The Distribution Characteristic Of TCM Type Of Syndromes And Their Relationships With HBVDNA And Hepatic Fibrosis Markers In Patients With HBe Antigen-negative Chronic Hepatitis B

BackgroundChronic hepatitis B(CHB) is a frequently encountered and common disease,which has been a big health problem in worldwide.People experienced CHB is up to 400 million.CHB can be divided into hepatitis Be-antigen(HBeAg) positive CHB and HBeAg negative CHB according to the condition of HBeAg.From the past years,there have been some differencis occured to CHB,of which the most remarkable is that the quantity of patients experienced HBeAg negative CHB,whose prognosis is considered worse than HBeAg positive CHB by more and more investigators,increases year by year.So it become necessary that we should treat HBeAg negative CHB specially while doing researches.But it is abjective that a majority of clinical researches about the distribution characteristics of Traditional Chinese Medicine(TCM) type of syndrome of CHB are carried out in panties with CHB not in patients with HBeAg negative CHB.There are only a few researches about the distribution characteristics of TCM type of syndrome but hardly about the relationship between TCM type of syndrome and laboratory tests in patients with HBeAg negative CHB.To resolve the problem,we design this investigate.ObjectiveTo investigate the distribution characteristics of Traditional Chinese Medicine(TCM) type of syndrome in panties with HBe antigen-negative chronic hepatitis B and research the correlation between syndrome types and serum levels of glutamic-pyruvic transaminase(ALT),glutamic-oxaloacetic transaminase(AST),relationship of deoxyribonucleic acid(DNA),liver fibrosis markers such as typeⅢprocollagen(PCⅢ),laminnin(LN),typeⅣcollagen(CⅣ) and hyaluronate(HA).MethodsThe basic information,clinical symptoms and several lab examination results such as liver function,the level of HBVDNA replication,four markers of liver fibrosis including PCⅢ,LN,CⅣand HA in 301 patients with HBeAg negative CHB were investigated.Results1.The proportions of TCM type of syndromes in 301 patients included the survey with HBe antigen-negative chronic hepatitis B were:liver depression and insufficiency of the spleen＞dampness-heat accumulation＞liver-kidney Yin deficiency＞obstruction of colletarals by blood stasis＞insufficiency of both the spleen and the kidney.2.The relationships between TCM type syndromes and ALT,AST were:The serum levels of ALT and AST in the second syndrome were significantly more higher than the other syndromes,(P＜0.05),and there is no difference among the others.3.The relationships between TCM type syndromes and replication of HBVDNA were:when the range of replication of HBVDNA below 10~4 copies/ml,the frequency of dampness-heat accumulation syndrome is remarkably less than other syndromes,and there is no difference among the others;when the range of replication of HBVDNA within 10~4copies/ml to 10~6 copies/ml,the frequency of dampness-heat accumulation syndrome is remarkably more than other syndromes, and there is no difference among the others.4.The relationships between TCM type syndromes and the serum levels of liver fibrosis markers were:the proportion of liver-kidney Yin deficiency syndrome with abnormal LN and HA is more than liver depression and insufficiency of the spleen syndrome and dampness-heat accumulation syndrome: dampness-heat accumulation syndrome has more patients with abnormal PCⅢthan liver depression and insufficiency of the spleen syndrome;There is no difference between the rate of abnormal CⅣwithin liver depression and insufficiency of the spleen syndrome and that within dampness-heat accumulation syndrome.ConclusionsThe distribution of TCM type of syndromes of the patients with HBeAg-negative chronic hepatitis B has its characteristic.There is some relationship between 5 syndromes and the levels of AST,ALT,replication of HBVDNA,four markers of liver fibrosis.