| To explore the effect of aerobic exercise joint dietary control on the visfatin plasma levels in type 2 diabetic rats and analyze the changes in other relevant indicators. Method:Chose 62 single of 6-week-old SD rats which were male, Eight rats were randomly selected as normal control group of rats (Control, C group), and fed with normal standard diet. The remaining 54 SD rats which were feed high-fat and high-sugar diet were injected of low-dose streptozotocin though abdominal cavity to establish animal models of type 2 diabetes. and then the rats of type 2 diabetes were randomly divided into 4 groups : DM control group (n=9), DM+ aerobic exercise training group (n=10), DM+ Diet control group (n=10), DM+ aerobic exercise training + Diet control group (n=10). The DM group's rats which were continued to feed high-fat and high-sugar diet were not exercise; Exercise were used 60 minutes'unloaded swimming for 13 weeks, 6 times per week; The dietary control use the general contour of the standard diet of the DM group. 13 weeks later, FPG, TG, TC, FINS, Visfatin of every group's rats were examined. Results:①After 13 weeks of the establishment of type 2 diabetes model, compared with C group, the FPG contents increased significantly in DM group(P<0.01); Through the double factor variance analysis, aerobic exercise can lower FPG levels in diabetic rats (P<0.05), And the effect of dietary control on FPG levels in diabetic rats did not significantly(P>0.05), exercise joint dietary control did not display an obvious interaction on lowering FPG levels in diabetic tats(P>0.05). ②After 13 weeks of the establishment of type 2 diabetes model, compared with C group, the serum insulin concentration decreased significantly in DM group(P<0.01), but the HOMA-IR was no significant changes. Through the double factor variance analysis, diet control can increase the FINS level in diabetic rats significantly(P<0.05), aerobic exercise and aerobic exercise joint dietary control in diabetic rats could further increase the level of FINS, but no significant interaction(P>0.05); there was neither significantly effect of aerobic exercise nor dietary control to improve the DM group of HOMA-IR(P>0.05), and there was no significant interaction(P>0.05).③After 13 weeks of the establishment of type 2 diabetes model, compared with C group, the visfatin plasma concentrations significantly increased(P<0.01); Through the double factor variance analysis, there was significant impact of 13 weeks of strength training for swimming to lower plasma visfatin concentrations in diabetic rats; compared with the DM group, Although the visfatin plasma concentration lowered too much in DMD group, through the double factor variance analysis, there was no significant impact of dietary control to lower the visfatin plasma concentration(P>0.05); aerobic exercise and diet control can further reduce the visfatin plasma concentration in diabetic rats,and there was no significant interaction(P>0.05).④After 13 weeks of the establishment of type 2 diabetes modle, compared with C group, the serum total cholesterol concentration and the serum triglyceride concentration increased significantly(P<0.01); Through the double factor variance analysis, both of aerobic exercise and dietary control could significantly lower the total cholesterol concentration in type 2 diabetic rats(P<0.05), and there was significant interaction of both aerobic exercise and dietary control to lower the total cholesterol concentration in type 2 diabetic rats(P<0.05). Dietary control could lower the triglyceride concentration in type 2 diabetic rats(P<0.01)significantly, but aerobic exercise could not , although aerobic exercise joint dietary control could further lower the triglyceride concentration in type 2 diabetic rats, there was no significant interaction (P>0.05).Conclusion:①Establishing of the Model of type 2 diabetes in this research was successful. Dietary control only could not effectively lower the FPG concentration; And aerobic exercise training has a very significant role to control the FPG of diabetic rats, on the base of the diet control, aerobic exercise training was more effective to reduce the fasting plasma glucose levels which in diabetic rats. At the same time, the visfatin plasma levels which in type 2 diabetic rats was significantly increased.②13 weeks of aerobic exercise training could improve the capacity of which Pancreaticβ-cell secreted insulin in type 2 diabetes rats; Although aerobic exercise joint dietary control could increase the insulin concentration in type 2 diabetes rats, and it had a very important role in the treatment of type 2 diabetes, there was no significant interaction.③Aerobic exercise could significantly lower the level of visfatin plasma in type 2 diabetic rats ; There was little effect on lowering the visfatin plasma concentration of 13 weeks of dietary control in type 2 diabetic rats; Aerobic exercise joint dietary control could further lower the visfatin plasma content in type 2 diabetes rats, but there was no significant interaction; And there was a close relationship between blood glucose levels and visfatin levels. It might be a main factor on regulating the visfatin's synthesis and secretion.④It was an active role in improving lipid metabolism for aerobic exercise training,dietary control and aerobic exercise joint dietary control. At the same time, it was also a role in regulating the lipid metabolism for visfatin plasma levels, However, the precise relationship between them had to be further studied. |
PDF Full Text Request