Observation The Effect Of Hugan Pill On The Patients Of Syndrome Of Stagnation Of Liver And Spleen Deficiency With Dampness-heat Of Liver And Gallbladder With Chronic Hepatitis B

Objective:To observe the validity and safety of Hugan pill on patients with syndrome chronic hepatitis B of syndrome of stagnation of liver and spleen deficiency with dampness-heat of liver and gallbladder.Meanwhile this research try to investigate the effect of the change of dosage form.MethodsChoose the patients of syndrome of stagnation of liver and spleen deficien -cy with dampness-heat of liver and gallbladder with chronic hepatitis B as ob -serving objects.Sixty cases were randomly divided into 2 groups,each 30,one for treatment and the other for control,observed by double blind method.For treatment group,treated by Hugan pill,otherwise in control group,Hugan tablet was used.The treatment course of this research is 12 weeks,the 3rd month for the follow-up visit.The study was designed to observe the change of the clinical symptom physical sign,Traditional Chinese medicine syndrome integral,Hepatic function(concluding ALT,AST,ALB,GLB,ALP,GGT,TBIL and DBIL),B supersonic wave on liver and spleen,and secure index(conclud -ing blood,urine,stool routine and renal function,ECG),comparing the tharapeutic efficacy of both drugs. Results:1.The curative effect of enzyme dropping:The treated group:obvious effective rate is 20.69%,and total effective rate is 51.72%;the controlled group:obvious effective rate is 13.79%,and total effective rate is 41.38%.The effective rate of treated group was better than that of the controlled group,but there aren't statistics difference between two groups(P>0.05).2.The curative effect of traditional Chinese medicine syndrome:The treated groups:obvious effective rate is 31.03%,and total progressive rate is 79.31%;the controlled group:obvious effective rate is 17.24%,and total effective rate is 68.97%.The effective rate of treated group was better than that of the controlled group,but there aren't statistics difference between two groups(P>0.05).3.The curative effect of ALT:The treated groups:obvious effective rate is 31.03%and total progressive rate is 82.76%;the controlled group:obvious effective rate is 20.69%and total effective rate is 75.86%.The effective rate of treated group was better than that of the controlled group,but there aren't statistics difference between two groups(P>0.05).4.The curative effect of AST:The treated groups:obvious effective rate is 24.13%,and total progressive rate is 58.62%;the controlled group:obvious effective rate is 20.69%and total effective rate is 44.82%.The effective rate of treated group was better than that of the controlled group,but there aren't statistics difference between two groups(P>0.05).5.The curative effect of TBil,DBil:The treated groups:obvious effective rate is 23.08%,and total progressive rate is 57.69%;The controlled group:obvious effective rate is 16.67%,and total effective rate is 41.67%.The effective rate of treated group was better than that of the controlled group,but there aren't statistics difference between two groups(P>0.05).6.The curative effect of blood plasma albumen:There are some progress on two groups in the end of experiment,but there isn't statistics difference (P>0.05),and there isn't statistics difference between two groups(P>0.05).7.The safety index:the two groups were not discovered adverse reaction and harmful effect on cases.There was not abnormal change on blood,urine, stool routine and renal function,ECG of cases.Conclusion:Hugan pill has better curative effect on chronic hepatitis B of syndrome of stagnation of liver and spleen deficiency with dampness-heat of liver and gallbladder than that of Hugan tablet for Nourishing Liver on the 12^th week, but it has the same curative effect as the compared drug on the fllowe-visit. Hugan pill can well improve symptom and physical sign of the patients of syndrome of stagnation of liver and spleen deficiency with dampness-heat of liver and gallbladder with chronic hepatitis B,progress Hepatic function, lighten the damage of liver.It hasn't the serious side effects in this clinical research.The Hugan pill is the effectual and secure medication to syndrome of stagnation of liver and spleen deficiency with dampness-heat of liver and gallbladder with chronic hepatitis B from the research.