Clinical Value Of CT Scan Combined With Determination Of Serum Tumor Markers In The Diagnosis Of Nonsmall-cell Lung Cancer

Objective To evaluate the clinical value of CT scan combined with determination of serum levels of tumor markers in the diagnosis of nonsmall-cell lung cancer. And offer the most important evidence for clinical treatment plan .Materials and Methods Eighty cases with nonsmall-cell lung cancer were pathologically confirmed . They were divided into two groups : 46 cases of squamous cell cancer, 34 cases of adenocarcinoma. Meanwhile to select 20 cases of lung benign diseases as control group. Plain chest film, CT scanning were taken and peripheral blood CYFRA21-1, CEAwere estimated in all patients. And part of cases undertook CT contrast enhanced scan . To analyze the CT manifestation of NSCLC and they were typing and staging according to their imaging characteristic. To study correlation among serum tumor markers, pathologic patterns and cilinical stage of pulmonary carcinoma. As a result we evaluate the significance of correct diagnosis rate of CT scan combined with determination of serum tumor markers for NSCLC.Results CT diagnosed 31 cases of squamous cell cancer, 22 cases of adenocarcinoma. The correct rates of CT and the serum tumor markers for nonsmall-cell pulmonary carcinoma were 66.3% and 51.3%, respectively. The former was obviously higher than the latter (P<0.05). Contents of serum tumor markers in lung cancer patients were higher than those in lung benign disease patients (P<0.01). The levels of serum CYFRA21-1, CEA were related to types of pathology. The highest diagnostic sensitivities were 76.1% for CYFRA21-1 (17.83±12.06) in squamous cell cancer, while the highest one for CEA (47.26±28.36ng/ml) was 70.6% in adenocarcinoma (P<0.01). The diagnostic concordance rates with pathology type were 66.3% and 51.3% through CT and tumor markers respectively, combined detection concordance rate was 81.3% (P<0.05). The sensitivity, specificity and diagnostic efficiency of CT in staging of lung cancer was 77.9%, 78.6% and 85.2% respectively. The serum level of tumor markers were increased as advancement of the stage, but the positive rate of serum tumor markers were no significant difference among stageⅢtoⅣ. Sensitivity and specificity were increased when CT combined with tumor markers.Conclusion CT scan combined with serum tumor markers could increase diagnosis rate of NSCLC, and its accuracy of pathologic patterns and cilinical stage. So they were helpful for clinician to exactly evaluate lung cancer preoperatively and adopt reasonable treatment plan .