| Objective This research aims to observe the therapeutic use of added Yinchenhao decoction to acute viral cholestatic hepatitis,to discuss its therapeutic effect and the effect to nitric oxide,to offer some clinical evidences for the curative effect.Method A randomized controlled trial was adopted in the clinical study.88 patients who were diagnosed acute viral cholestatic hepatitis were divided randomly into a treatment group(45cases) and a control group(43cases).The two group were treated with conventional therapy: Diammonium Glycyrrhizinate 30mland Glutathione 1.2g for injection. control group treated with potassium aspartate and magnesium aspartate 20ml for injection and took Anethol Trithione 25mg per time,three times a day.While the treatment group were treated with added Yinchenhao decoction(Yinchen,Zhizi,Jinqiancao,Dahuang,Zhenzhucao,Danshen,Fabanxia.etc) granula,At the beginning,2 weeks and 4 weeks,The liver function(TB,DB,ALT,γ-GT)and nitric oxide(NO) were observed:At the beginning,1 week and 4 weeks,the blood,urine,renal function and electrocardiogram of the two groups were observed to evaluation its clinical effect.Statistical analysis software SPSS10.0 was adopted. t analysis was taken by measurement data,X~2 analysis was taken by count data,Ridit was taken by comparatine analysis of efficacy.And then compose the statistical comparison.Result With the level of total bilirubin(TB),the treatment group was superior to the control group(79.6±8.6/95.2±12.8umol/L) at 2 weeks(P＜0.05),the treatment group was superior to the control group (38.3±10.2/55.1±11.9umol/L) at 4 weeks(P＜0.01).With the level of direct bilirubin(DB),there was no superior difference between the two groups at 2 weeks,While the treatment group was superior to the control group(27.2±12.5/32.7±15.3umol/L) at 4 weeks(P＜0.05).The improvion of ALT,two groups were both improved.While there was no superior difference between the two groups at 2 weeks,the treatment group was superior to the control group(52.5±10.9/65.0±11.6U/L) at 4 weeks(P＜0.05).The improvion ofγ-GT,there was no superior difference between the two groups at 2 weeks(P＞0.05),While the treatment group was superior to the control group(39.1±13.9/51.9±16.3U/L) at 4 weeks(P＜0.05).With effect in NO,the treatment group was superior to the control group(103.5±18.5/115.9±20.3umol/L) at 2 weeks(P＜0.05),While the treatment group was superior to the control group(83.4±13.5/97.2±15.7umol/L) at 4 weeks(P＜0.01).With aspect of improving clinical symptoms,the treatment group fully recovered 28cases,effective 13 cases,invalid 4 cases,compared with the control group(10 cases,25 cases,8 cases),there was superior difference (P＜0.05).At 4 weeks,the rate of markedly improved of the treatment group was 31.1%,the rate of effective was 60.0%,the rate of invalid was 8.9%,compared with the control group(20.9%,53.5%,25.6%),there was superior difference(P＜0.05).The blood,urine,renal function and electrocardiogram of the two groups were normal.In the treatment,there were no serious adverse reactions.In a word the treatments were safe.Conclusion added Yinchenhao decoction could accelerate the meta bolism of bilirubin of the patients with acute viral cholestatic hepatitis,decrease the level of NO,resisting injury the liver cells, improve the clinical symptoms.It's effection may concer with:①added Yinchenhao decoction could promotes the excretion of bilirubin, dredges the aisle of bilirubin excretion;②blocks the circle of enterohepatic,decreases reabsorption;③resisting injury to liver, recovering function of liver,included the absorbion,combination,excretion of bilirubin.There are no adverse reactions.The treatment is safe and effective. |
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