| Background:Progressive ischemic stroke(PIS)is simply referred to as Stroke in progression(SIP).As an important ischemic cerebral stroke subtype, SIP refers to a kind of acute cerebral infarction that neurological function will deteriorate,even die whether being treated or not after 6 hours after onset of ischemic stroke. It is a state involving many relevant factors ,more complex pathogenesis and mechanisms. Disability and death rates of patients with SIP are significantly higher than those with non-SIP. The neurological doctors are being confronted with an austere challenge from SIP. It will be of important clinical significance to establish a scoring system (scale) including a variety of factors related with the SIP. This scoring system (scale) will be used to early prediction of the SIP in order to take active measures to prevent its occurrence or to minimize its damage.Objective:This study aim at exploring the variational regularity of pathogenetic condition at different general clinical parameters levels and accomplishing some accumulation of the basic datum to be used to establish the above scale through the stratified investigation from the general clinical parameters of 336 patients with acute cerebral infarction. It is also one of purposes to investigate preliminarily the variational regularity of nitric oxide (NO) level during the course of the disease and to analyze its possible causes through detection of NO level in blood serum of part patients with SIP,non-SIP and control group.Methods: A total of 336 patients with cerebral infarction who presented within the 24 hours of onset were enrolled from June in 2007 to September in 2008. They were divived into two groups:100 patients in SIP group and 236 patients in non-SIP group by the change of SSS from 6 hours to 9 days after onset. The general clinical parameters(including deterioration beginning time,age, sex, history of hypertension, diabetes history, smoking history, admission blood pressure, body temperature and infection, etc.) were detailed. NO in blood serum of part patients with SIP,non-SIP and control group were detected. The statistical analyses of above results were performed using SPSS for Windows version 11.5 or 13.0.Results:1. In 336 patients with cerebral infarction , 100 cases are SIP patients with an incidence rate of 29.8 percent. Most of SIP occurred within 1 week after onset and 98(98%) cases during 6h-1w after onset. 69(69%)cases during 6-72h after onset,therein,38(38%)case during 6-24h after onset.2(2%)case during the 9th d after onset.2. There is no statistical difference between male group and female group.3. There is a significant difference between higher age group(≥75y)and lower age group(<75y)and for SIP incidence rate,the former(63.6%)is significantly higher than the latter(26.1%).4. There is a significant difference between random two of group with hypertension history of 20 and more than 20 years, group with hypertension history of less than 20 and group without hypertension history, and for SIP incidence rate, the former (49.4%)> the intermediary (30.0%)> the latter (16.8 %).5. There is a significant difference between random two of group with diabetes history of 10 and more than 10 years, group with diabetes history of less than 10 and group without diabetes history, and for SIP incidence rate, the former (62.0%)> the intermediary (34.3%)> the latter (18.5 %).6. There is no statistical difference between random two of group with smoking index of 400 and more than 400,group with smoking index of less than 400 and no history of smoking.7. There is a significant difference between group with mean arterial pressure(MAP)≤ 75mmHg and 75mmHg |
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