Differential Expression Of CD133,Glut1 In Tissues And Endothelial Cells Derived From Infantile Hemangioma And Vascular Malformation

Skin hemangiomas is a common and benign tumor, which frequently occurs in infants and children. Infantile hemangiomas is characterized by proliferation of endothelial cells. And it grows rapidly after birth but slowly regresses during early childhood. angiogenesis inhibitor. The fundmental reason of occurrence and development on hemangioma is mainly about functional characteristic of vascular endothelial cells derived from hemangioma. The one opinion is that it derives from mutational precursor cells. The other opinion is that it derives from placenta microvessel endothelial cells .Objective To investigate the expression and significance of CD133,Glut1 and precursor cell,placental microvessel endothelial cells in the occurrence, development and regression of infantile hemangiomas.Methods We examined the expression and significance of CD133,Glut1 in the occurrence, development and regression of infantile hemangiomas and congenital vascular malformation postnatal vascular malformation using immunohistochemical technique. An image analysis system (Image-pro plus 5.0.1) was used to measure the average integrated optical density and the rate of positibe area of CD133 and Glut1 in different stages of hemangiomas and in vascular malformation. Results The expression of CD133 was significantly higher in differential stages congential hemangioma,congential vascular malformation,placenta chorionic villi than postnatal vascular malformation (P<0.05). About the expression of Glut1, there was difference between proliferating hemangiomas,placenta and degenerating hemangiomas,vascular malformation (P<0.05).Conclusion The precursor cells marked CD133 may be the source of endothelial cells derived from congential hemangiomas and congenital vascular malformation. Glut1 may supply energy to endothelial cells and promote endothelial cells proliferating.