Cardiac Dysfunction Is Associated With Acute Cerebral Infarction And Its Adverse Impact: A Prospective Study Of 150 Consecutive Cases

Background: It is well known that patients who have cerebrovascular accidents havean high incidence of cardiac complication. At present, lots of researchers pay closeattention to the cardiac dysfuncthion by studying ECG abnormalities, serum level ofenzyme change and other abnormal appearances. In addition, the AHA/ASA guidelinealso highlights the importance of cardiac test. However, the clinic data of cardiacdysfunction related to patients in China is still deficient.Object: The purpose of this study is to investigate the cardiac complication onclinical change after acute cerebral infarction, as well as the impact of this onshort-term and long-term effect.Method: We selected 150 consecutive inpatients suffering from a cerebral infarctionfrom 13 hospitials in shanghai. All these inpatients were examined within 48 hours ofthe onset of symptoms. The tests were performed on their admission to hospital, andthereafter on the seventh day. These tests incldue 12-lead ECG, serum level ofenzymes including LDH, CK, CK-MB, AST, TnT, MHb. The patients will befollowed up when they were discharged from hospitals using mRS, and 90±2 dayslater.Result: Our study showed the results that 72.8% ECG were already abnormal while81.8% in serum enzymes. The abnormal ECG detected in patients with unfavourableshort-term outcome reached to 82.0%, with a significant (P<0.05) prevalencecompared to 65.3% in favourable short-term outcome ones. Abnormality of serumlevel of enzymes showed no significant difference between patients with favourableor unfavourable short - term outcomes. While 90 days later, the serum level ofenzymes indicated a higher ratio of abnormal conditions in patients with unfavourableoutcome than those with favourlable outcome, especially the enzymes test taken onadmission.Conclusion: Our results indicate that the high incidence of cardiac complication afteracute cerebral infarction has been identified in this study, and it will lead to anunfavourable prognosis of cerebral infarction. espetially when the abnormalisitionsapperent during the first 48 hours.