The Effect On The Levels Of The Inflammation Factors Of IL-18 And Hs-CRP In Patients With ACS From Application Of Statins

Objective:To detect the levels of interleukin-18(IL-18) and high sensitivity C-Reactive protein(Hs-CRP) in patients with acute coronary syndrome(ACS) before and after taking atrovastatin,To explore the relationship of IL-18 and Hs-CRP and the severity of coronary heart disease,to explore the effect on inflammation factors from statins.Methods:Sixty-five patients with acute coronary syndrome were enrolled and divided into two groups by single -blinded way:fifty patients were as study group,who were treated by atrovastatin;fifteen patients were as control group,who were not treated by atrovastatin.The other treatments were same in both groups.5ml blood were collected from peripheral vein before and after treatment for 4 weeks with atrovastatin.IL-18 was measured with ELISA methods and HS-CRP was measured with automatic biochemistry analysis instrument.T-test statistical method and F-test statistical method were applied, the levels of IL-18 and HS-CRP of the patients with ACS were compared before and after taking atrovastatin and not taking atrovastatin for 4 weeks in both groups.Results:The levels of Hs-CRP in study group(n=50) were 14.7160±6.8027mg/dl and 2.6180±2.0913 mg/dl respectively before and after treatment for 4 weeks,which were different significantly(p＜0.01);The levels of IL-18 in study group(n=50)were 1.2869±4.9766ng/l and 0.8411±0.3473ng/l before and after treatment for 4 weeks respectively,which were different significantly too(p＜0.01).The levels of Hs-CRP in control group(n=15) were 12.6733±4.9766 mg/l and 6.5600±3.2839mg/l respectively before and after treatment for 4 weeks,which were different significantly(p＜0.01);The levels of IL-18 in control group(n=15) were1.2941±0.1799 ng/l and 1.0374±0.1930ng/l before and after treatment for 4 weeks,which were different significantly(p＜0.01).By F-Test,the levels of HS-CRP and IL-18 in both groups were not different before treatment,but the ones in both group were different significantly after treatment(P＜0.01).Conclusion:The levels of serum inflammation factors including IL-18 and Hs-CRP in study group were decreased significantly after treatment for 4 weeks with artovastain, which were different from ones in control group significantly.It was possible that atrovastatin have anti-inflammation effect on patients with ACS.