Influence Of Different Doses Of Rosuvastatin Treatment On High-sensitivity C-reactive Protein And Interleukin-6in Patients With Acute Coronary Syndrome

Objective:To investigate the effect of different doses of rosuvastatin on serum high-sensitivity C-reactive protein (hs-CRP) and interleukin-6(IL-6) in patients with acute coronary syndrome (ACS).Materials and methods:72ACS patients were randomized into high dose group (n=36, rosuvastatin was20mg/d based routine therapy)and low dose group (n=36, rosuvastatin was10mg/d based routine therapy). Each group was given the same base treatments,and taken the different dose rosuvastatin for4weeks.At the same time,70cases as a control group received coronary angiography because of chest pain with normal results.Levels of blood lipids,serum hs-CRP and IL-6were measured before the treatment and after the treatment,harmful reaction was monitored at the same time.Results:Levels of total cholesterol (TC), low density lipoprotein (LDL-C) C,serum hs-CRP and IL-6in two groups were significantly decreased (P<0.01),high density lipoprotein (HDL-C)C was significantly rosed (P<0.05).After the treatment, levels of serum hs-CRP and IL-6were decreased more significantly in the high dose group than those in the low dose group(P<0.01),the same results in the AMI and UA groups, but the harmful reaction was no difference(P<0.05).Conclusion:Rosuvastatin may reduce the levels of serum hs-CRP and IL-6in ACS patients in the early time,especially high dose,while harmful reaction did’t increase.