Detection The Concentration Of Serum High Sensitive C-reactive Protein(hsCRP),IL-6,TNF-α,Renin,AngiotensinⅡ In Patients With Atrial Fibrillation And Its Significance

objective:To explore link of change of high sensitive C-reactive protein(hsCRP),IL-6,TNF-α,renin,angiotensinⅡand atrial fibrillation(AF).Methods:69 atrial fibrillation patients were divided into three groups:Paroxysmal atrial fibrillation group(27 cases),persistent atrial fibrillation group(19 cases).Permanent atrial fibrillation group(23 cases) and control group(sinus rhythm,21cases).The serum high sensitive C-reaetiveprotein(hs-CRP),IL-6,TNF-α,renin,angiotensinⅡcontent and left atrial diameter (LAd),ejection fraction(EF)in each group were measured by enzyme - linked immunosorbent assay (ELISA) and eehocardiography.Results:Patients with Paroxysmal atrial fibrillation and persistent atrial fibrillation and Permanent atrial fibrillation had high levels ofhs-CRP,IL-6,TNF-α,renin,angiotensinⅡwhen compared with the healthy subjects.Patients with persistent atrial fibrillation and Permanent atrial fibrillation had high levels of hs-CRP,IL-6,TNF-α,renin,angiotensinⅡwhen compared with Paroxysmal atrial fibrillation.No significant changes of hs-CRP,IL-6,TNF-α,renin,angiotensinⅡlevels were found between the persistent atrial fibrillation and Permanent atrial fibrillation.The LAd of Paroxysmal atrial fibrillation and persistent atrial fibrillation and Permanent atrial fibrillation group was significantly different from that of sinus rhythm group(P＜0.01 ).The LAd of paroxysmal atrial fibrillation group was insignificantly greater than that of sinus rhythm group(P＞0.05).Conclusion:There is significant increase of hsCRP,IL-6,TNF-α,renin,angiotensinⅡlevel in patients with atrial fibrillation.Thus,it indicates that the inflammatory reaction and the activation of RAAS may promote the occurrence and maintenance of atrial fibrillation.