The Clinical Study Of Guchong Zhixue Decoction In Treating Anovulatory Dysfunctional Bleeding With Qi Deficiency And Blood Stasis Syndrome

ObjectiverTo observe the effect of Guchong Zhixue Decoction (GCZXD) in treating dysfunctional uterine bleeding (DUB) of anovulatory type with Qi deficiency and blood stasis syndrome , and to systematically explore its hemostasis mechanism。Methods: 60 patients of DUB diagnosed Anovulatory Dysfunctional Bleeding with Qi deficiency and blood stasis were randomly divided into the treated group(30 cases, treated by GCZXD taken orally ) and the control group(30 cases,treated by Yigong ningxue Oral Liquid,taken orally). Observe the changes of the hemostasis effect the improvements of clinical symptoms, thickness of endometrium , the blood rheology, the uterine blood circulation, prothrombin time (PT), activated partial prothrombin time(APTT), the serum Ca²⁺ level , 6-keto-PGF_1α(6-K-PGF_1α) and thromboxane B₂(TXB₂) in the menstrual blood. Results: The total effective rate of GCZXD in hemostasis was 93.3% in the treated group, which was significantly better than that in the control group (70.0%,P<0.05). Significant difference was shown in improving clinical symptoms, thickness of endometrium, the blood rheology, the uterine blood circulation, PT, APTT, the serum Ca²⁺ level, 6-K-PGF_1α and TXB₂ in the menstrual blood in the treated group when compared with before treatment (P<0.05,P<0.01) also when compared with the control group after treatment (P<0.05). Conclusion: Guchong Zhixue Decoction has favorable hemostatic effect in treating dysfunctional uterine bleeding of Qi deficiency and blood stasis syndrome, and it can also improve the accompanied symptoms significantly.