The Experimental Research Of The Changes Of IL-1 In Gingival Crevicular Fluid For The Diabetes Who Acceped Prosthetics After Losing Their Teeth

Objective:To investigate the changes of IL-1 in gingival crevicular fluid(GCF) afterthe patients used RPD, we prevent the occurment of denture stomatitisand other infecting diseases. So we can offer theoretic support for thediabetes to periodontitis,diabetes to other oral diseases and for the choiceof oral restoration to diabetic patients.Methods:1 .After six months for the Co-Cr RPD fmished,the follow-up visit wereused for the diabetic patients and collators. The GCF were collected fromthe gingival crevice. The differences of IL-1 in different patients weredetermined by ELISA and the differences were comparaed.2.In follow-up visit, we observed the gingival index(GI) of patients intwo groups and analysed the results.Results:1.For the diabetic patients ,the IL-1 concentration of abutments wasdistinctly higher than before and higher than non-diabeticpatients,too ;while in non-abutments there were no statistics meaning forthe IL-1 concentration.2.The indexes of clinical results showed that the gingival index ofdiabetic patients had no difference to normal patients if the oral hygiene was proper.Conclusion:1. ELISA is a effective measure for determining the IL-1 concentrationsin gingival crevice.2.The IL-1 concentration in gingival crevicular fluid could reflect therestroration's influence to the condition of gingival tissue, so offertheoretical basement for clinical applications.3.For the diabetic patients,a proper restorations is important formaintaining the gingival indexes,so offer theoretical basement for clinicalapplications.