The Association Between MinkS38G Polymorphism And Atrial Fibrillation In The Chronic Heart Failure Patients

Objective: To investigate the association between mink gene S38G polymorphism(minkS38G) inβ-subunit of Iks potassium channel and atrial fibrillation(AF) in the chronic heart failure patients.Methods: One hundred and twenty-seven patients with chronic heart failure admitted to the Cardiovascular Department of the Second Affiliated Hospital of Chongqing Medical University from February 2007 to November 2007 were selected in this study, in which,63 patients have atrial fibrillation(AF group) and 64 patients have sinus rhythm(SR group). Venous Blood samples and clinical data of the patients were collected. Mink S38G polymorphisms were determined by PCR-RFLP. Associations of mink S38G polymorphisms with atrial fibrillation in chronic heart failure patients were analysized by test and multivariate logistic regression (SPSS verion 13.0).Result: The distributions of mink genotypes and alleles matched Hardy-Weinberg Law. The results showed an association between mink 38G allele and atrial fibrillation. The frequency of three genotypes(AA,AG,GG) in two groups: AA(9.52%/23.44%),AG(41.27%/50.00%), GG(49.21%/26.56%). The distribution of three genotypes in the atrial fibrillation patients were significantly different from those in the SR groups (P=0.013). Multivariate logistic regression analyses demonstrated that mink 38G allele was significantly associated with susceptibility to AF in chronic heart failure patients(Multivariate logistic regression OR=0.481,95%CI 0.276-0.838,P=0.010).Conclusion: The mink 38G allele is superion in the patients with atial fibrillation to that in the SR group, there was significant difference between the tow group. The chronic heart failure patients with mink 38G alleles have hight risk to atrial fibrillation. Our findings suggest possible genetic control on the pathogenesis of atrail fibrillation.