The Expression And Significance Of Ki-67 And P27 In Adrenocortical Tumors Tissue

Objective:To study the expression of Ki-67,P27 in adrenocortical tumors,and its relationship with adrenocortical carcinoma and adrenocortical adenoma.Methods:The methods of S-P Immunohistochemistry was used to detect the expression of Ki-67.P27 in adrenocortical carcinoma(10cases),adrenocortical adenoma(60cases)and normal adrenocortical tissue(12cases).and the expression of Ki-67.P27 was analyzed with relation to adrenocortical carcinoma and adrenocortical adenoma.Results:1.There is significant difference in the expression of Ki-67 between adrenocortical carcinoma and adrenocortical adenoma,and the positive rate of adrenocortical carcinoma is significant higher than that in adrenocortical adenoma.2.There is significant difference in the expression of P27 between adrenocortical carcinoma and adrenocortical adenoma,and the positive rate of adrenocortical carcinoma is significant lower than that in adrenocortical adenoma.3.There is the highest expression of Ki-67 and the lowest expression of P27 in adrenocortical tumors.There exist negative correlation between the expression of Ki-67 and P27(P＜0.05).There is significant difference in the LI of Ki-67 and that of P27 between adrenocortical carcinoma and adrenocortical adenoma(P＜0.01).The cutpoint of LI of Ki-67 was 4%and the cutpoint of P27 was 13%in adrenocortical carcinoma.Conclussions:It is suggested that combine detecting the expression of Ki-67 and P27 may be taken as one of biomarkers for differentiation of adrenocortical adenomas from adrenocortical carcinomas.The LI of Ki-67 above 4%and LI of P27 below 13%,is a sensitive indicator of adrenocortical carcinoma.