Preliminary Research Of The Influence Of The Frequency In ESWL To Renal Damage And Efficiency

Partâ… :Objective:The purpose is to finding the influence of ESWL frequency to the organization and kidey function,according to comparing the pathological changes in rabbit kidney and renal function under different frequencyMethods:54 healthy white rabbits,aged 3.5-month-old male,2.3-2.7 kg, were divided into three groups and anesthesiaed by 3%pentobarbital sodium 40 mg/kg intraperitoneal,contrast agent was injected into ear intravenous,Under the guidance of C-arm X-ray we located to the renal pelvis,and operated to the rabit,in accordance with 60times/min,90 times/min,120 times/min-frequency on each side of the renal.One day and.14 days and 28 days respectively after the operation the SCr,BUN serum-Na~+,CCr urine-Na~+ and FENa were determined,and at the same time the microstructrue of renal damaged by SWL was observed by light microscop.Results:The first day after EWSL,SCr,BUN,CCr,FENa increased with the increase of frequency and shocks,but returned to preoperative levels in 14 days.At the first day after ESWL,the renal damage aggravated as the increase of frequency.At the 14 days and 28 days after ESWL,in terms of the pathological score,no significant differences were observed between 60 times/min -groups and 90 times/min-groups,but 120 times/min-group was greater than the fisrt 2 groups.Conclusion:1.There was a transient decline of renal function after ESWL.2.The acute damage aggravated as the increase of frequency.3.There was chrionic damage as fibrosis after ESWL and no significant difference was observed in 60 times/min-group between 90 times/min -group.4.Decrease of frequency was helpful to reduce renal damage after ESWLPartâ…¡:Objective:The purpose is to study the efficiency and damage in ESWL according to preliminary retrospective clinical trial.Method:After retrospective analysis of 180 cases that were confirmed by X-rays and B-ultrasonography form September 2003 to December,the cases were divided into 3 group:60times/min,90times/min and 120times/min.There were 102 males and 78 females aged 18 to 55.And the stones were 8mm to 20mm.STORZ MEDICAL MODULITH SLK lithotriptor,the electromagnetic energy was 60-65 J and the number of SWL was 3500-4000.The complications and the SWL number needed were records.All the patients one month after ESWL were detected by radiography of the kidneys,ureters,and bladder and B-ultrasonography. Residual stones less than 4 mm was accepted as being cured. Results:The difference of the success rate between 60 times/min group and 90 times/min-group was not significant,but significantly higher than 120 times/min group.A statiscally significant difference was observed in the complications between 60 times/min-group and 120times/min group and between 90times/min group and 120times/min group.However,no statistically significant difference was noted between 60 times/min group and 90 times/min group.The difference in ESWL duration was statistically significant between 60 times/min and 90 times/min and between 60 times/min group and 120 times/min group,but no statistically significant difference was observed between 90 times/min group and 120 time/min group.Conclusion:1.Decrease of ESWL frequency was helpful to increase the success rate, The difference of the success rate between 60 times/min group and 90 times/min-group was not significant,but significantly higher than 120 times/min group.2.Decrease of ESWL frequency was helpful to reduce the complications.A statiscally significant difference was observed in the complications between 60 times/min-group and 120times/min group and between 90times/min group and 120times/min group.However,no statistically significant difference was noted between 60 times/min group and 90 times/min group.