Expression Of CD117,CD34 And Ki-67 In Gastrointestinal Stromal Tumors And Its Correlation With Clinicopathological Factors And Risk Rank Of GISTs

Objective:To investigate the expression rates and the expression levels of CD117,CD34 and Ki-67 in gastrointestinal stromal tumors(GISTs) and its relationship with the clinicopathological features and risk rank of G1STs.Methods:To detect the expression rates and the expression levels of CD117,CD34 and Ki-67 in 57 cases of GISTs by immunohistochemical S-P,and to analysis the relations of immunohistochemistry of the above indicators and related clinicopathological factors(gender, age,location).To further explore the relationship of the rank of risk and immunohistochemistry of the above indicators.Results:The positive expression rates of CD117 and CD34 were 84.2%and 71.9%.;There had no significant difference in the different gender,age group,intestinal and parenteral on the positive expression rates of CD 117 and CD34(P＞0.05).There had no significant difference in the different gender and age group on the positive expression rates of CD34.The positive expression rates of CD34 in parenteral is higher than that of intestinal.The positive expression intensity of CD34 had no significant difference in different rank of risk.The positive Expression intensity of CD 117 and the proliferation index of Ki-67 is significant different in the different rank of risk(P＜0.05).The positive expression intensity of CD 117 and the proliferation index of Ki-67 was positively correlated with risk classification.Conclusion:CD117 and CD34 in GIST was in high expression levels,and had a certain significance in the diagnosis of GIST.However,the expression intensity of CD34 can not be used as a risk indicator of GIST.And the expression intensity of CD117 and the proliferation index of Ki-67 was positively correlated with risk classification.They may be one of the reliable indicators in judging the risk of GIST.