Study On Relationship Between Thyroid Autoantibodies And Recurrent Spontaneous Abortion

Objective: To study the relationship between thyroid autoantibodies,such as thyroglobulin antibody(TgAb) and thyroid microsomal antibody(TMAb)),and recurrent spontaneous abortion(RSA) patients whose thyroid function are normal.Methods: 50 non-pregnant women with histories of RSA were served as study subjects ,30 healthy women with normal histories were served as controls.Determining the two groups'serum of TgAb,TMAb and the levels of thyroid stimulating hormone(TSH) by immunoradiometric assay,of antinuclear antibody(ANA),anticardiolipin antibody(ACA) by Gold immunodot assay.Results:①The positive rates of TgAb and TMAb in the serum of study subjects were 16% and 16% respectively,which were higher than the rates of controls as 6.7% and 3.3%,howere,there were no significant differences between the two groups(p>0.05);The positive rates of ANA and ACA in the serum of study subjects were 28% and 46% ,which were obviously higher than the rates of controls as 6.7% and 20%,there were significant differences between the two groups(p<0.05).②Divided the study subjects into two groups of A(The number of abortions≥3) and B(The number of abortions<3).The positive rates of TgAb and TMAb in the serum of group A were 29.2% and 29.2% respectively, which were obviously higher than the rates of group B as 3.8% and 3.8%,there were significant differences between the two groups(p<0.05).③Divided the study subjects into two groups of C(The duration of pregnancy of abortion≥12weeks) and D(The duration of pregnancy of abortion<12weeks).The positive rates of TgAb and TMAb in the serum of group C were 3.7% and 3.7% respectively, which were significantly lower than the rates of group D as 30.4% and 30.4%,there were significant differences between the two groups(p<0.05) ; The positive rate of ACA in the serum of group C was 66.7%, which was obviously higher than the rate of group D as 26.1%.,there were significant differences between the two groups(p<0.05).Conclusion: The positive rates of TgAb and TMAb in the study subjects were higher than the rates of controls,howere,there were no significant differences between the two groups,so TgAb and TMAb could not be considered as casual factors in RSA,they may be one kind of the secondary logo of autoimmune abnormality.TgAb and TMAb may forecast many times and early abortion for RSA patients.