| Objective To observe the expression of platelet CD62P, CD63 in patients with acute cerebral infarction (ACI) with different risk factors, and compare the effects of aspirin and clopidogrel on it, and provide reliable theoretical references for the prevention and therapy of acute cerebral infarction.Methods 68 cases of patients with acute cerebral infarction were randomly divided into two groups: aspirin treatment group and clopidogrel treatment group. The expression of platelet CD62P and CD63 was measured by flow cytometry before and after treatment. Observe and compare the influence of the different risk factors on its expression, and the different drugs (aspirin and clopidogrel) on its expression.Results The expression of platelet CD62P and CD63 in patients with acute cerebral infarction was obviously higher than that in normal control group. Hypertension, diabetes and hyperlipoproteinemia can accelerate the expression of platelet CD62P and CD63, and can activate platelet. In both the aspirin treatment group and the clopidogrel treatment group, the expression of platelet CD62P and CD63 was obviously lower after treating. The expression of CD62P and CD63 in the clopidogrel group was obviously lower than that in the aspirin group, the differences were significant.Conclusions The activation of platelet plays a main role in the pathogenesis of acute cerebral infarction. Hypertension, diabetes and hyperlipoproteinemia can aggravate the occurrence of acute cerebral infarction by enhancing the activation of platelet. For the patients with acute cerebral infarction, both aspirin and clopidogrel could inhibit the activation of platelet, and the clopidogrel was more powerful, probably has more clinical efficiency. |
PDF Full Text Request