The Clinical Research On Aspirin And Clopidogrel Loading Dose Treatment Of Acute Cerebral Infarction/TIA

ObjectiveTo explore the effectiveness and safety of the treatment of acute cerebral infarction /TIA by combing aspirin and clopidogrel in pairs of loading dosages (300mg)MethodsSelect 97 patients admitted within 24 hours onset of acute cerebral infarction/ TIA(both carotid system), who were randomly divided into two groups,one was aspirin and clopidogrel group(treatment group:the first dose of clopidogrel 300mg+aspirin 300mg, aspirin 100mg+chlorine 75mg for 29 days; 47 cases); the other was aspirin group (control group:first dose of aspirin 300mg, after the 100mg for 29 days,50 cases). NINSS rating criteria was used to evaluate ischemic stroke in accordance with valid and invalid. TIA standards for the effective treatment were that seizures non-attack after 14th day.To observe clinical results, side effects and complications on the 7th and 30th day, and explore the changes of serum CRP and the relationship between it and clinical manifestations.ResultsThe efficiency after 7 days later, the aspirin and clopidogrel group was 89.36%, while the aspirin group was 72%, the two groups had significant differences (P<0.05); After 30 days, the efficientcy of aspirin and clopidogrel group was superior to aspirin group (P <0.05). TIA in the treatment group was all effective, Two patients in the control group were invalid. None of the serious side effects such as bleeding, gastrointestinal reactions, bone marrow suppression, skin rashes and so on. Changes of serum CRP levels was statistically significant (P<0.01) before and after treatment in aspirin and clopidogrel group.ConclusionCompared with aspirin for a single load, it was efficient that Aspirin and clopidogre pairs of loading dose treating acute cerebral infarction/TIA,which can effectively prevent the progress of stroke,improve the prognosis, reduce the relapse rate and fewer adverse reactions. The reseach can also showe aspirin and clopidogrel in combination can significantly reduce the levels of inflammatory factors and inhibit acute cerebral infarction during the inflammatory response and reduce cerebral ischemic injury.