The Comparative Study On The Effect Of Tranquilizer Of Zhongzhen Anshen And Yangxin Anshen On The Sleep Phase Of Insomnia Rats

Sleep is an essential process for life.It is an important link for rebounding organism,conforming and consolidating memory.Meanwhile sleep is an obbligato ingredient for health.Sleep disorder is a common ailment and simultaneous phenomenon of multiple ailments.We always use two types of mind-easing Chinese medicines to treat sleep disorder.Typeâ… is "Zhong Zhen An Shen" and Typeâ…¡is "Yang Xin An Shen".The clinical practice for thousands years proves that these two types of Chinese medicines have unique curative effect on improving sleep and enhancing sleep quality.Under conditions of constant temperature,constant humidity,lighting (12/12)and electromagnetic shielding,the experiment was performed. Through the methods of EEG and electric foot-shocks to make rats insomnia, we observed that the effect of Yang Xin An Shen(Baiziren,Yuanzhi, Suanzaoren)and Zhong Zhen An Shen(Cishi,Zhusha)on the sleep phase of insomnia rats and compared the two experimental results.The experimental results indicated that:1.Compared post-electric stimulation with pro-electric stimulation, these five experimental groups could obviously decrease the duration of W and increase SWSI,TST.It indicated that building the model of insomnia is succeeded.2.Compared post-administration with pro-administration,Baiziren, Yuanzhi,Suanzaoren of Yang xin An Shen and Cishi,Zhusha of Zhen An Shen all could decrease the duration of W and increase TST.It indicated five Chinese medicines all could improve sleep.3.Compared post-administration with pro-administration,Baiziren, Yuanzhi of Yang Xin An Shen could increase SWSI;Suanzaoren of Yang Xin An Shen could increase SWS₁ and SWS₂.It indicated that the different medicines of Yang Xin An Shen have distinct effects' on the sleep phase of insomnia rats. 4.Compared post-administration with pro-administration,Cishi,Zhusha of Zhong Zhen An Shen all could prolong SWS₁,SWS₂ and REMS.It indicated that Cishi and Zhusha have the same effect on the sleep phase of insomnia rats.5.Cishi,Zhusha of Zhong Zhen An Shen could prolong REMS,but Baiziren,Yuanzhi of Yang Xin An Shen couldn't.It indicated that Yang Xin An Shen and Zhong Zhen An Shen have distinct effects on the sleep phase of insomnia rats.6.Pro-electric stimulation and pro-administration,the result of comparing five groups didn't have significant difference on SWS₂,TST.7.Comparing five groups on SWS₂,TST after post-administration,we found that:the magnitudes of SWS₂,TST induced by Cishi were greater than Baiziren,Yuanzhi,Suanzaoren did;the magnitudes of SWS₂,TST induced by Zhusha were greater than Baiziren,Yuanzhi,Suanzaoren did; the magnitudes of SWS₂,TST induced by Cishi and Zhusha were the same. We considered that Cishi and Zhusha of Zhong Zhen An Shen were greater in improving sleep quality of insomnia rats.