Coxsakievirus, Coxsackie And Adenovirus Receptor And Non-small Lung Cancer

Objective To discuss expression of CVB and CAR in NSCLC,and to study the relationship among CAR,CAR and the development of NSCLC.To discover new pathogeny of lung cancer and to optimize adenovirus vector-based gene therapy.Methods The expression of CAR and CAR in 120 cases of NSCLC,paraneoplastic epithelial tissue and 5 normal lung tissues was examined using immunohistochemistry.At the same time,the relationship among CAR and CAR expression and clinicopathologic characteristics was analyzed.Results1.Expression of CAR:All staining on the cell membrane,little in normal lung tissue. Compared with paraneoplastic tissue,CAR is up-regulated in tumor tissues.The possitive rate in squamous cell cancers was 26.67%,and in adenocinoma 31.46%.It shows that CAR and NSCLC are positive correlation(squamous cell cancers, r=0.29277,adenocinoma,r=0.32579).We noticed that 27 cases are positive in 32 bronchioalveolar adenocinoma,positive rate 86.38%.However,the difference in adenocinoma except bronchioalveolar adenocinomas,in stages of squamous cell cancer,in sex,age,tumor diameter,metastasis had no statistical significance had no statistical significance.The difference between tumor tissues of two types, paraneoplastic tissue,had no statistical significance.So our results did not show that CAR expression is needed for the formation of tumors by a subset of SNCLC.2.Expression of CVB:All intracellular staining,little in normal lung tissue. Compared with paraneoplastic tissue,CVB is up-regulated in tumor tissues.The possitive rate in squamous cell cancers was 30.00%,and in adenocinoma 12.36%.It shows that CVB and NSCLC are positive correlation(squamous cell cancers, r=15.09317,adenocinoma,r=5.28281).The difference in stages of squamous cell cancer,between tumor tissues,in age,tumor diameter,metastasis had no statistical significance,but had statistical significance in paraneoplastic epithelial tissue.It shows that CVB expression is correlate with squamous cell cancers closer than adenocinoma,and with 16.98%positive rate higher than in adenocinoma.15.10% positive rate in male higher than female shows that CVB infect easier in male.3 the correlation between CAR and CVB:CAR and CVB are positive correlation in NSCLC(r=0.25128),squamous cell cancers(r=0.37741),adenocinomas(r=0.29638), adenocinoma except bronchioalveolar adenocinomas(r=0.39590),but zero correlation in bronchioalveolar adenocinomas,maybe because of the little cases.Conclusion1 There is positive correlation between squamous cell cancers,bronchioalveolar adenocinomas and CAR,zero correlation between adenocinomas except bronchioalveolar adenocinomas and CAR,no relationship between stages of squamous cell cancer,sex,age,tumor diameter,metastasis and CAR.Our results did not show that CAR expression is needed for the formation a subset of SNCLC.This research provides a basis for planning a regimen of gene.2 There is positive correlation between NSCLC and CVB,no relationship between stages of squamous cell cancer,age,tumor diameter,metastasis and CAR.Statistical significance in paraneoplastic tissue shows that CVB expression is correlate with squamous cell cancers closer than adenocinoma,and CVB infect easier in male.Zero correlation between paraneoplastic epithelial tissue of two typies.At the first time,we discovered enteroviruses could cause lung cancer,and found a new pathogeny of lung cancer.And it needs further test.3 It is positive correlation between CAR and CVB in NSCLC.