Clinical Study On Treatment Of Idiopathic Pulmonary Fibrosis With Tongluo Fiber Particles

Objective: This experiment takes Chinese medicine theories as an instruction, to observe the clinical effect of tongluo fiber particles on idiopathic pulmonary fibrosis (IPF) patients.Methods: 60 cases patients with idiopathic pulmonary fibrosis were randomly divided into two groups,the treatment group (30 cases) and the control group (30 cases). All patients were given drugs for 3 months and were observed two treatment stages.The treatment group was treated with Tongluo fiber particles and Prednisolone. The control group was treated with Prednisolone.The changes of clinical symptoms and signs, the pulmonary function test, blood gas analysis,the HRCT,the occurrence of lung reinfection rate and the make use of antibiotic were observed before and after the treatment.Results: The total effective rate was 83.33% in the treatment group ,better than 60.00% of the control group(P<0.05). The total symptom and sign scores in two groups all decreased than pre-treatment (P<0.01, P<0.05), after the treatment group decreased more significantly (P<0.05). The treatment group with significantly increased the pulmonary function index such as TLC, VC, Dlco compared than pre-treatment(P<0.05). In both group,PaO2 all decreased than pre-treatment,but the treatment group with significantly increased PaO2 compared to the control group(P<0.05). The HRCT results showed there was no significant difference between groups(P>0.05). The occurance of lung reinfection and the make use of antibiotic in the treatment group were lower than the control group within the treatment period and the difference between was significant(P<0.05).Conclusion: Tongluo fiber particles could not only improve the clinical symptoms and signs, the pulmonary function,increase PaO₂,but also reduce the occurance of lung reinfection rate and the adverse effects. Meanwhile, it could delay the course of pulmonary fibrosis, enhance the existent quality of patients.