Clinical Research On Infection After Allogeneic Hemopoietic Stem Cell Transplantation

Clinical Research on Infection After Allogeneic Hemopoietic Stem Cell TransplantationObjective To investigate the incidence and clinical characteristics of infection after allogeneic hemopoietic stem cell transplantation (allo-HSCT) for the patients with hematologic malignancies.Methods There have been in all 162 patients who received allo-HSTC for hematologic malignancies in PLA general hospital from April 1985 to April 2007. Among them, the clinical data of the cases occurred postoperative infection were retrospectively analyzed in this research.Results In the total 162 patients who received allo-HSCT, there were 149 cases with infection occurred within 30 days after the transplantation, with the infection rate of 91.9%. In the study, total 1843 specimens of body fluid from the patients were detected, and 549 strains of pathogenic bacteria were segregated from them (bacterium 487, fungus 62). The categories of the pathogenic bacteriawere as below, bacterium: Streptococcus viridans, Neisseria, Staphylococcus epidermidis, Coagulase negative staphylococcus, Baumanii, Escherichia coli and Klebiella pneumoniae, etc.; fungi: Candida albicans, Candida tropicalis, Candida parapsilosis, Yeast-like fungus and Aspergillus, etc. There were 35 cases infected human cytomegalovirus (CMV) after transplantation, with the infection rate of 21.6%. Among those cases, there were 11 cases suffered interstitial pneumonitis which were induced by the CMV, with the rate of 31.4% in the CMV infection cases. The 11 cases all died. All the CMV infection cases had the background of GVHD.Conclusions Infection is one of the major complications of allo-HSTC. In clinical practice, early diagnosis, regular monitoring, timely and proper treatment are very crucial for decreasing the occurrence of postoperative infection and enhancing the achievement ratio of the transplantation.