Investigation Of Organic Injury And Changes Of Cytokines In Paraquat Poisoning

Objective To observer the manifestation, liver and renal function, arterial blood gas , lung HRCT of paraquat poisoning patients, and we also determine the serum cytokines PDGF,IGF-1,TNF-α,IL-1β,IL-6,IL-10 of the patients.Methods 10ml venous blood was drawn from 38 paraquat poisoning patients 48h later after taking poisoning for liver and renal function determination and cytokines detection. Arterial blood gas and lung HRCT were also been done at the same time. 38 volunteers were invited as control. The determination of liver and renal function,arterial blood gas according to routine methods and the detection of cytokines according to the instruction of kits by ELISA.Results Paraquat could induce respiratory system, digestive system and urinary system manifestation. The serum ALT, AST, TBIL, BUN, Cr were increased by paraquat (P<0.05 or P<0.01, compared with control). PO₂, PCO₂, pH,BE,HCO₃^-were decreased by paraquat (P<0.01, compared with control). Cytokines PDGF,IGF-1,TNF-α,IL-10 were increased by paraquat.Conclusion Paraquat could induce lung, kidney and liver injury and cytokines may play an important role on the pathogenesis of paraquat poisoning.