The Study Of Gastric Sensory Function In Functional Dyspepsia Patients By Water Load Test

Part I Study on the Relation between Gastric Sensory Function and Early Satiety in Functional Dyspepsia Patients Objective To study the relation between gastric sensory function and early satiety in functional dyspepsia patientsMethods The gastric sensation threshold were assessed in 48 FD patients(divided into early-satiety and non early-satiety subgroup) and 20 healthy volunteers by water load test.The volume of water load was regarded as first satiety threshold when subjects reported the initial perception such as epigastric filling and bloating during water drinking.The volume was max satiety threshold when subjects got full satiety.Results FD patients had significant lower gastric sensation threshold for both first satiety and full satiety evoked by drinking water(433±60.2 ml vs 503±32.4ml and 784±90.8ml vs 1030±84.8ml,p<0.01respectively)compared with normal people.There was no significant difference of these parameters in the sex of both healthy people and FD patients(normal:510±34.3 ml vs 495±30.3 ml,p>0.05 and 1053±91.0 ml vs 1006±73.5 ml,p>0.05,FD patients:441±58.9 ml vs 425±61.6 ml,p>0.05 and 794±80.3 ml vs 773±100.4 ml,p>0.05 respectively). There was no significant difference of parameters in the subgroup of FD patients. (430±61.7ml vs 437±59.6ml,p>0.05 and 779±95.1 ml vs 788±87.9 ml,p>0.05). About 50% FD patients had hypersensitive gastric first satiety threshold. 75% FD patents had hypersensitive gastric full satiety threshold.Conclusions Gastric hypersensitivity exists in FD patients. There was no significant difference of parameters in different sex in FD patients. There was no relation between gastric sensory function and early satiety in functional dyspepsia patients. Part II The Study of Gastric Sensation Threshold in Functional Dyspepsia Patients by Water Load Experimentation in Different TemperatureObjective To study gastric sensation thresholds in functional dyspepsia patients and healthy volunteers after drinking water in different temperature.Methods The gastric sensation thresholds were assessed in 48 FD patients and 20 healthy volunteers by water load test.The study was performed by drinking 37℃or 4℃pure water at different time. The volume of drinking water was regarded as first satiety threshold when subjects reported the initial perception epigastric filling and bloating during water drinking.The volume was max tolerance threshold when subjects got full satiety.Results(1)FD patients had significant lower gastric sensation threshold for both first satiety and full satiety evoked by drinking 37℃and 4℃water(p<0.01). The first satiety and full satiety threshold were lower at 4℃than 37℃group in healthy people, while, there is non-significant difference. The full satiety threshold was significantly lowered at 4℃than 37℃in FD patents(p<0.01). The difference of maximum hydroposia tolerance threshold between different temperature in normal group is obviously less than that of FD group at 37℃and 4℃(p<0.05).(2)There was no significant difference of parameters in different subgroups of FD patients at 37℃and 4℃group.Conclusions Gastric hypersensitivity exists in some FD patients, it includes mechanical extension and cool irritation sensation. There was no relation between gastric sensory function and early satiety in functional dyspepsia patients in different temperature.