Clinical Research About Function Of Gastric Accommodation And Gastric Emptying In Different Types Of Patients With Functional Dyspepsia

Objective: Using LNLT to evaluate gastric accommodation and gastric emptying in FD patients and HS,combined SF-36 quality of life scale and hospital anxiety and depression scale for investigating the pathophysiological mechanism of gastrointestinal motility.Methods: 1.Patients Recruitment:A total of 74 subjects,including 60 patients with FD and 14 healthy subjects,were studied. All the patients were recruited from January 2014 to December in Wuhan NO.1 Hospital Gastroenterology outpatient,all patients were satisfied the diagnosis of FD,and divided according to the diagnostic criteria of TCM symptom three deficiency syndrome:spleen deficiency and qi stagnation syndrome,spleen dampness syndrome and spleen deficiency syndrome.2.Methods:All subjects performed liquid nutrient load test,combined with ultrasonography to delineate the objects or areas of stomach:proximal and distal stomach volume.Recording the threshold volume and maximum threshold volume of drinking,calculating the rate of gastric emptying,gastric half-emptying time.Meanwhile,the subjects filled the SF-36 scale and HAD scale.3. Statistical analysis:All data were collected using SPSS 19.0 softwarefor statistical analysis.With bilateral difference test,P value was greater than 0.05 was not statistically significant.Results: 1.There was no significant difference between the FD group and the HS group(P>0.05) in terms of gender, age. 2.Compared with HS group,the maximum threshold volume of drink was significantly difference in FD patients(P<0.05).FD group was lower than HS group at the threshold drink, but no significant difference(P>0.05).The maximum threshold volume in the three TCM syndromes were lower than HS group(P<0.05), the threshold drink was no significant difference between the three syndromes.Spleen dampness type was lower than spleen qi stagnation and spleen deficiency type at the maximum threshold volume(P<0.05),but no significant difference in the threshold drink(P>0.05). 3.In FD patients,the distal gastric emptying rate at 60 min,90min after LNLT was significantly lower than the HS group(P<0.05),no significant differences in the proximal gastric emptying rate.The distal gastric emptying of FD group was longer delayed compared with HS group(P<0.05),the proximal stomach and distal gastric emptying rate were no difference among the three groups TCM FD syndromes(P>0.05),but the distal gastric emptying rate at 90 min of spleen deficiency syndrome was significantly lower than HS group(P<0.05),the proximal stomach and distal gastric emptying time of spleen dampness type was longer delayed than HS group,spleen qi stagnation and Spleen deficiency type(P<0.05). 4.The HAD depression score of FD patients was significantly higher than HS group(P<0.05),but no significant difference in anxiety score(P>0.05);the depression scores of spleen qi stagnation was significantly higher than HS group(P<0.05),spleen dampness syndrome of anxiety scores were significantly lower than the HS group and Spleen deficiency syndrome(P<0.05).SF-36 scale score of FD group in physiological function, emotional function were lower than the HS group(P<0.05),but higher than HS group in terms of higher physical pain(P<0.05);the three kinds of syndromes at physiological functions of the scores were lower than the HS group(P<0.05),spleen qi stagnation was significantly lower than the HS group in terms of emotional function score,spleen qi stagnation and spleen yang deficiency syndrome were significantly lower than the HS group in terms of physical pain score(P<0.05),below the spleen deficiency type Spleen dampness in terms of mental health scores.Conclusions: Through the liquid nutrient load test,the maximum intake of drinking and gastric emptying rate,gastric emptying half-time reflect the gastric accommodation and gastric emptying dysfunction of FD subjects,and suggesting that gastric accommodation diastolic function and gastric emptying is an important mechanism of FD.The spleen dampness syndrome gastric with diastolic dysfunction compared with spleen qi stagnation and spleen deficiency syndrome,and the gastric emptying of spleen dampness syndrome was longer delayed than the other syndromes.FD patients were poor than the healthy in the quality of life.which spleen qi stagnation serious than the other syndromes.