Study Of Correlations Between Plasma Opestatin And Relevant Factors In The Population Of Different Glucose Tolerances

Objective: To investigate the changes of plasma Obestatin leves, and assess the association between plasma Obestatin and body mass index (BMI), HOMA-insulin resistance index (HOMA-IR),blood glucose,blood fat, plasma insulin levels as well as other factors in the popul-ation with different glucose tolerances.Methods: Plasma Obestatin levels were measured by radioimmu-noassay in the patients with type 2 diabetes mellitus(T2DM) and im-paired glucose regulation(IGR), and controls (NGT). The relationshipbetween plasma Obestatin levels and BMI, HOMA-IR, plasma glucose, insulin, blood fat levels were also analyzed by bivariate, multivariate regression and multivariate logistic regression analysis.Results:Plasma Obestatin levels in patients with IGR and T2DMwere significantly reduced compared with controls[(39.2±9.7)ng/L and(37.5±9.2)ng/L vs (43.8±8.0)ng/L, P﹤0.05 and P﹤0.01]. Plasma Ob-estatin levels were also found to be markedly decreased in obese su-bjects when compared to subject with BMI≤25 kg/m2 (37.2±9.8ng/L vs 42.4±8.2ng/L, P=0.003). Plasma Obestatin levels correlated negativ-ely with BMI, 2hPG, HbA1c,WHR, plasma insulin and HOMA-IR(r=-0.201, r=-0.010, r=-0.219, both P﹤0.05 and r=-0.261, r=-0.279, r=-0.345,all P﹤0.01)in simple regression analysis. But in a multiple re-gression analysis, only HOMA-IR and WHR were independently ass-ociated with plasma Obestatin levels(r=-0.443, P﹤0.01 and r=-0.218,P﹤0.05). Decreasing concentrations of obestatin were independently and significantly associated with IGR and T2DM. Multiple logistic r-egression analysis revealed Obestatin as an independent association f-actor for T2DM, even after full adjustment of known biomarkers.Conclusion: The changes of obestatin levels are associated with metabolism disorder, and it may contribute, in part, to the pathogene-sis of IGR and T2DM.