Relationship Between Expression Of The P53 Protein, DNA Ploidy And Clinicopathological Features In Colorectal Cancer

Objective To study the relationship between expression of the p53 protein, DNAploidy and clinicopathological features in colorectal cancer.Methods The p53 protein were examined by immunohistochemistry S-P in 80example specimen which were obtained from colorectal cancer patients by surgicalresection between Oct, 2002 and Oct, 2005 in the 1^st hospital to NingBo, ZheJiang. DNAcontent of corresponding specimen were examined by flow cytometry. Results To beexamined, expression of the p53 protein and DNA ploidy have no significant differencerespectively in patients with different age, sex, tumor sizes, depths of invasion, types oftissue. But expression of the p53 protein and DNA ploidy have significant differencerespectively in patients with different the location of tumor, tumor cell differentiation,lymph node metastasis. The positive rates of p53 protein expression were 70% incolorectal cancer patients. The positive rates of the aneuploid tumors were 76.25%, thepositive rates of DI＞1.9 in the aneuploid tumors were 56.25%. To be examined, they havesignificant difference respectively.Conclutions P53 played an important role in turnorgenesis and development ofcolorectal cancer. P53 protein and DNA content could be used indicators in evaluationprognosis of colorectal cancer.