Diagnostic Values Of Serum Orexin-A Levels In Childrens With Obstructive Sleep Apnea-hypopnea Syndrome

Objective:we conducted the present study to assess the clinical usefulness of the measurement of orexin-A concentration in serum as a diagnostic predictor to screen patients with obstructive sleep apnea-hypopnea syndrome(OSAHS)in children. Methods:serum orexin-A concentration were measured with EIA kit in 60 patient with snoring before performing polysomnography(PSG).subsequently all the subject underwent PSG test.Forty subjects were diagnosed as having OSAHS,and twenty subjects were without OSAHS.These 20 non-OSAHS subjects served as controls. Compare with the PSG results;assess the clinical usefulness of the measurement of orexin-A concentration in serum as a diagnostic predictor to screen patients with obstructive sleep apnea -hypopnea syndrome(OSAHS)in children.Correlation between orexin-A levels and AHI,MAI,LSaO2 were analyzed.Result:the serum orexin-A levels in the OSAHS group[(0.49±0.10)ng/ml]was significantly higher than the control group [(0.28±0.11)ng/ml,P＜0.01],If a patients level of orexin-A more than 0.36ng/ml,these patient more likely with OSAHS.The sensitivity rate was 85.0 and the specificity was 80.0%.serum orexin-A levels in children with OSAHS correlated positively with the AHI(r=0.427,P＜0.05)and MAI(r=0.468,P＜0.05),but correlated negatively with the lowest oxygen saturation(LSaO2)(r=-0.527,P＜0.01)and the mean oxygen saturation (MSaO₂)(r=-0.541,P＜0.01),not correlated significantly with the BMI(r=-0.212,P＞0.05).the serum orexin-A levels in the OSAHS children's after 3 month significantly decreased(P＜0.05)than that of pre-operation.Conclusion:these findings suggest that the serum level of orexin-A could be used as a predictor in screening OSAHS children and a biological marker of the severity of OSAHS children.