The Application Of Renalhematuria In Kidney Disease Diagnosis And The Evaluation Of Its Detection

Backgrounds:Many ways are used to localize the source of bleeding in the urinary tract inpatients presenting with hematuria, but the optimal choice is still to be. Recently, agreat progression has been made. 113 cases that have been proved to beglomerular diseases were collected. Phase contrast microscopy(PCM) and flowcytometry (FCM) were applied to each urine sample respectively. This study is aim toexplore the value of glomerular hematuria in diagnosis in renal disease and estimate thetwo techniques, then achieve more thorough diagnosis of the site of bleeding.Aims:Explore the value of glomerular hematuria in diagnosis in renal disease andestimate the two techniques.Methods:105 cases that have been proved to be glomerular disease were collected. Urinespecimens were examined separately by Phase contrast microscopy (PCM) andflow cytometry (FCM). The source of bleeding were identified referring toClinical and pathological materials, the two techniques are compared. Statisticalanalysis: x2 Test, t-test and one-way ANOVA were carried out by spss 11.5software.Results:1 Statistical significance is detected between quantification of hematuriaexamined by Phase contrast microscopy(PCM) and the proliferation ofmesangium. 2 Statistical significance is detected between quantification of hematuriaexamined by uf-100 and the proliferation of mesangium.3 No Statistical significance is detected between IgA Nephropathy andglomerulonephritis with the same degree of mesangium proliferation.4 In some cases, examination results do not Coincide.6cases werediagnosed as glomerular hematuria by PCM while non glomerularhematuria by FCM.10 cases were diganosed as glomerular hematuria byFCM while non glomerular hematuria by. PCM5 6 cases were diagnosed as mixture hematuria BOTH by PHM and FCM.6 6 cases with low-grade hematuria and proteinuria (＜0.5g/L)were included.7 12 cases with high-grade hematuria and proteinuria were included.Conclusion1. Mesangium leisions were detected out in all Cases with Glomerularhematuria. Generally, the grade of hematuria correlate with the degree of Mesangiumleisions. But in some cases with severe hematuria, Mesangium leisions are notobvious.2. Cases that was proved to be glomerular lesions by renal biopsy werediagnosed as non glomerular hematuria by lab techniques .As for these cases,the degree of pathological lesions is various.3 Hematuria alone can not represent the whole of renal lesions, correctdiagnosis must base on the general judge of clinical materials.4 FCM Could be a useful way to help localize the site of hematuria when clinical diagnosis do not coincide with report of PCM.