TNF-a Levels And Effect In Expressed Prostate Secretion Of Patients With Chronic Abacterial Prostatitis

Objective: To investigate the levels of TNF-a in expressed prostaticfluids (EPS) of patients with chronic prostatitis/chronic pelvic painsyndrome(CAP/CPPS), and evaluate the significance of TNF-a to CAP/CPPS.Methods: To collect 40 patients with full history and record of diagnosisand treatment, and with the syndromes referred in NIH-CPSI, belonging totypeⅢfrom Outpatient Urologic Surgery and 8 normal health men. To testthe levels of TNF-a of EPS and normal men with ELISA method, Analyze thedifference among the three groups and the correlation between the levels ofTNF-a and the NIH-CPSI.Results: The TNF-a levels of group A and group B is higher than groupC in EPS, and group A is significantly higher than group B(p＜0.01). Thequantity of white blood cells in each of the three groups has no relationship tothe levels of TNF-a in EPS (P＞0.05). In group A and group B, the levels ofTNF-a in EPS have positive correlation with the pain syndrome score ofNIH-CPSI, and have no correlation with voiding syndrome score, livingcondition score and total score of NIH-CPSI.Conclusion: The levels of TNF-a in EPS of the patients withCAP/CPPS are higher than the normal men. The levels of TNF-a in EPS havepositive correlation with the pain syndrome score of NIH-CPSI, it may reflectthe activity of CAP/CPPS. The levels of TNF-a in EPS is help to differentiate theⅢA andⅢB.