The Clinical Investigation Of The Relationship Between Obstructive Sleep Apnea-hypopnea Syndrome And Erectile Dysfunction

1. backgroundObstructive Sleep Apnea-Hypopnea Syndrome, OSAHS, is a higher morbidity chronic sleep anapnoea affection, epidemiology survey show the morbidity rate is 2%-4% in abroad, especially in male. in OSAHS patients, recurrent attacks of hypoxemia, the change of neuroendocrine and microarousal induce the damage of whole system of body, including the erectile dysfunction(ED). anatomical stenosis and obstruction of upper airway is the important cause of OSAHS. Uvulopalato-pharyngoplasty (UPPP)is the main treatment of OSAHS. at present, the reports of the clinical study of relationship between OSAHS and ED and whether the UPPP treatment can improve the ED in OSHAS patients are rare.2. The relationship between obstructive sleep apnea-hypopnea syndrome and erectile dysfunctionObjective: To explore the relationship between obstructive sleep apnea-hypopnea syndrome and erectile dysfunctionMethods: To select the male OSAHS patients 40 cases, the age between 31 and 65, the mean age 45.4±10.3. all subjects need to the sleeping centre do the monitoring of PSG, before the monitoring, we need collect some basic data, for example, the body height, the body weight, the body massive index(BMI), the neck collar(measure it on the cricovocal membrane), the Iternational Index of Erectile Function 5 (IIEF-5). in the mane sequenti after the monitoring, we draw-off the venous blood 3ml in the condition of empty stomach and sitting silently, select the serum after the centrifuge, to maintain it in一70℃, and that it can be used to measure the hormone (FSH,LH,PRL和T).Results: After the IIEF-5 measuring scale to examine itself, the patients of OSAHS use the IIEF-5 measuring scale to examine itself and the results is (13.8±2.2), the ED is 21 cases(52.5%), the healthy control group use the IIEF-5 measuring scale to examine itself (22.3±2.5), the ED is 2 cases(10.0%), the incidence rate of ED in OSHAS patients is higher than the healthy control group obviously (P＜0.05), the content of hormone (FSH,LH,PRL) in patients serum and the healthy is no different (P＞0.05), the T content of patients serum is lower than the control obviously. so it can reach the conclusion that the level of T hormone which is relative with sexual function is changed in OSAHS patients.conclusions: The OSHAS patients have the conspicuous ED, and such ED is closely associated with apnea hypopnea index, the minimal oxygen saturation and Testosterone.3. Effect of uvulopalato-pharyngoplasty (UPPP) therapy on erectile dysfunction in patients with obstructive sleep apnea-hypopnea syndromeobjective: To explore the influence of uvulopalato-pharyngoplasty (UPPP) treatment on erectile dysfunction (ED) in patients with obstructive sleep apnea-hypopnea syndrome (OSAHS).methods: To select the primary part patients 40 cases who have experienced the monitoring of PSG and have the request of operation, the age between 31 and 65, the mean age 45.5±10.6. all of them do the UPPP operation in the condition of complete anaesthesia, and measure the apnea-hypopnea index (AHI), the minimal arterial oxygen (minSaO2), the sexual hormone n serum (FSH,LH,PRL and T), the Iternational Index of Erectile Function 5 (IIEF-5)before the operation, and 6months after the operationresults: The AHI of pretherapy 3.3±2.4 in OSAHS patients is 45.4±12.3, and the AHI of post-treatment is 16.2±11.6, P＜0.05, the minSaO2 of pretherapy is 71.5±5.6, and the minSaO2 of post-treatment is 6.4±4.2, P＜0.05, the IIEF-5 of pretherapy is (13.8±2.2), the IIEF-5 of post-treatment is (20.3±1.8) P＜0.05, the content of FSH,LH,PRL in patients and the normal is no diffeent (P＞0.05), and the content of T hormone in pretherapy is 3.3±2.4, and the content of T hormone in post-treatment is 4.2±2.5, P＜0.05conclusions: The treatment of UPPP can improve the ED of the OSAHS patients, and the AHI,minSaO2 and T is the possible effective predict index.