The Influence Of Uvulopalatopharyngoplasty On High Sensitive C-creative Protein In Serum Of Patients With Obstructive Sleep Apnea Hypopnea Syndrome

Objective:To explore the changes of the serum high sensitive C-creative protein level in patientse who have been diagnosised as OSAHS and the effect of fatness on this change.Meanwhile we will explore the effects of uvulopalatopharyngoplasty(UPPP)on high sensitive C-creative protein(hs-CRP)in serum of patients with obstructive sleep apnea hypopnea syndrome(OSAHS).Method:We chose twenty patients as the experimental group who have been diagnosised as OSAHS and must be operated by UPPP after monitored by PSG in my hospital.Meanwhile we aslo chose twenty fat people without any other disease and twenty healthy people as two control groups.We compared these three groups in all index.The concentration of serum high sensitive C-creative protein(hs-CRP)level were measured with ELISA in the experimental group(n=20)and two control groups. The vein blood must be extracted before breaskfast in the morning.Three months after operation,OSAHS patients were monitored by PSG and serum high sensitive C-creative protein(hs-CRP)level were measured again.Result:1.BMI of The OSAHS group and that of the fatness group hsve no significant difference(P＞0.5).But other index have significant difference (P＜0.05).BMI and C-creative protein(hs-CRP)level of the fatness group and that of the healthy have significant difference(P＜0.05).The OSAHS group and the healthy have significant difference in all index(P＜0.05).Before treatment,there were significant positive correlation between hs-CRP and BMI in OSAHS patients (r=0.523,P＜0.01).significant negative correlation between hs-CRP and AHI (r=0.485,P＜0.05)and significant positive correlation between CRP and the average SaO2((r=-0.506,P＜0.05).2.After UPPP eighty percents patients felt the symptom had changed.Stenosis of cavity of pharynx of all OSAHS patients had been improved.In general the serum level of crp of twenty OSAHS patients have reduced significantly after operation(r=4.818,P＜0.001).The serum level of crp of sixteen patients had reduced fourty pecents,the level of two patients had not reduced,but heigntened on the contrary.Two patients had not changed significantly.On the other hand the AHI had reduced,it had statistical significance(r=10.01,P＜0.001).The AHI eighteen patients had reduced more than 25 pecents,three patients had changed only 12 pecnets,9 pecnets. The effective power is 90 pecents.And the serum level of crp of the three patients were also not reduced.And the average SaO₂ at night and minimum SaO₂ were heightened.Tht the BMI had not changed.Conclusion:1.The serum hs-CRP level of OSAHS patients and fat people were significantly higher than healthy people.C-reactive protein is the most valueable acute protein.All these can show that the highten of The serum hs-CRP level of fat people may have correlation with chronic inflammation in the fatness,especially centripetal fatness.Meanwhile,it also show that t the highten of the serum hs-CRP level of OSAHS people may have correlation with inflammation in uper respiration tube and apnea hypopnea.2.After UPPP the serum hs-CRP level of OSAHS patients declined significantly,this can show that the UPPP can relieve the obstruction of part uper respiration tube to improve the estation of low oxyhgen at night and sleep quality,and then than inflammation reponse allleviate quickly.UPPP can recede the AHI, meanwhile it can effect inflammation by topical mechanism.We can see that the UPPP is one kind of efficiency operation method to treat the OSAHS,because it can decline obviously incidence and mortality of Cardiovascular Disease.