| Objective: Osteoporosis and atherosclerosis are the main cause of morbidity and mortality in the aged people. They were considered as two independent disease process. In present study , bone density showed obviously correlation with severity of atherosclerosis after judgement of tradition risk factors of cardiovascular disease. Bone loss of femoral increased mortality of cardiovascular disease. Vascular calcification, a notable feature of atherosclerosis, was also a predictive factors of fracture of femur. In diabetes patients and postmenopausal women, people with osteoporosis frequently display vascular disease, so osteoporosis and atherosclerosis may be shared with the common risk factors and epidemiological changes. Several studies also indicated that atherosclerotic calcification as an organized and regulated process similar to bone formation. Local regulation of mineralization in bone and vessels is supported by similar complex cellular responses and local modulators.In order to investigate the relationship between diabetic osteoporosis and atherosclerosis, This study was conducted to measure BMD of the L(2)~L(4) lumbar vertebrae and left femur as an index of osteoporosis and the intima-media thickness(IMT) of the carotid artery was measured as an index of atherosclerosis. Then the correlation between BMD and IMT was examined.Methods: In this study, 52 postmenopausal women with type 2 diabetes mellitus, 50 healthy non-diabetic postmenopausal women were made as control group. All subjects were evaluated for BMD at L(2)~L(4) lumbar vertebrae and the femur (neck, trochanter, InterTro and total) by DEXA (dual energy X-ray absorptiometry),and for IMT by Color Doppler Ultrasound equipment. Diabetic duration, FBG, PBG and other indexes et al were recorded, then these data were evaluated for any relationship in respect to BMD and IMT measurements .Characteristics of subject obtained:①BMD were measured by OSTEOCORE 3 made in MEDI LINK (France)②IMT were measured by SEQUOIA512③hemoglobin A1c in blood were determined by DCA2000+(Bayer Co. Germany).④fasting plasma insulin(FINS), were measured with radioimmunoassay.⑤The patients'high and weight were recorded, body mass index was counted.Results1 Results of regression analysis1.1 Results of univariate linear regression. There are negative correlations between lumbar BMD with age, the diabetic duration, PBG, HbA1c, and IMT in diabetic patients, positive correlations with E2. There are negative correlations between total hip BMD with age, the diabetic duration, years of menopause, PBG, HbA1c, TC, LDL and IMT, positive correlations with E2, FIns. There are positive correlations between IMT with age, diabetic duration, years of menopause, PBG, HbA1c, TC, LDL and IMT, negative correlations with E2 in diabetic patients.1.2 Results of multiple regression analysis. BMD showed negative correlation with IMT after judgement of age, diabetic duration, years of menopause, PBG, HbA1c, TC, LDL, E2. The comparison of Characteristics in different groups2 The comparison of Characteristics diabetic group.2.1 In diabetic group, compared with the osteoporotic patients and non-osteoporotic patients, age and the course of the disease was significantly longer than that in non-osteoporotic patients (P<0.05). E2 and FIns were significantly lower than those in non-osteoporosis patients (P<0.05). FBG, PBG, HbA1c, TC, LDL and IMT were significantly higher than those in non-osteoporosis patients (P<0.05). IMT were significantly higher than those in non-osteoporosis patients after judgement of age (P<0.05).2.2 The comparison of Characteristics in diabetic and control group. There were no significant different in age, BMI between type 2 diabetic and control group. In diabetic group, FBG, PBG, HbA1c, FINS, TC, TG and LDL were significantly higher than those in control group (P<0.05), HDL and E2 were significantly lower than those in control group (P<0.05). BMD in diabetic group was found to be decreased at the lumbar, neck, trochanter and total of femur (P<0.05). IMT was found increased in diabetic group(P<0.05).3 The morbidity ratio of diabetic female after-manopause osteoporosis is 44.2%, 27.4 % in control group.Conclusions1 The diabetic patients and post-menopause female are easier to be developed the osteoporosis and atherosclerosis.2 Hyperglycemia, hyperlipemia, estrogen deficiency were the common risk factors of diabetic osteoporosis and atherosclerosis .3 Common mechanisms may underlie the pathogenesis of both atherosclerosis and osteoporosis. |
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