Clinical Analysis On Acute Exacerbation Of Chronic Obstructive Pulmonary Disease Treating With SHENFU Injection

Objective:1.Evaluating the clinical efficacy of SHENFU Injection treating acute exacerbation of chronic obstructive pulmonary disease(AECOPD),and observing its effects on the pulmonary function,adreno-corticotropin hormone,cortisol and cellular immune function in such cases.2.Investigating the application of Warming yang reinforcing qi Method in treating AECOPD.Methods:According to inclusion criterions,67 AECOPD patients from November 2005 to January 2007 in our hospital were divided randomly into two gruops,37cases as treated group, which were treated with SHENFU Injection and conventional therapy of western medicine.30 cases as controlled group, which were treated with conventional therapy of western medicine only.Then,according to Traditional Chinese Medicine(TCM) dialectic criterions,67 cases were divided into cold syndrome type(including cold spit TCM type and cold breathe TCM type) and heat syndrome type (including heat spit TCM type and heat breathe TCM type).There were 17 cases of cold syndrome type and 20 cases of heat syndrome type in treated group,13 cases of cold syndrome type and 17 cases of heat syndrome type in controlled group.All patients were given conventional therapy of western medicine such as controllable oxygen treatment,anti-infection,spasmolysis,dissipating phlegm and antasthmatic,and the treated group was added SHENFU Injection.The syndrome and objective sign were observed,as well as the pulmonary function,the levels in plasmas ACTH,cortisol and CD₃,CD₄,CD₈ were detected before treating and the first day after treating.At last,all data were analyzed by SPSS 13.0 for windows.Results:1.The treated group was superior to the controlled group in the curative effect and the relieving of TCM syndrome such as cough, expectoration, breathe(p〈0.05),but there were not significant differences between the two groups in rales(p〉0.05).It indicated that SHENFU Injection could improve the curative effect of AECOPD.2.After treatment,the pulmonary function was improved significantly in both groups(p〈0.01),but there were no significant differences between the two groups(p〉0.05).It indicated that there was no difference efficacy in improving the pulmonary function between the two treatments.3. After treatment,the level of ACTH and cortisol decreased significantly(p〈0.05),but the treated group's level of ACTH and cortisol were higher than the controlled group after treating(p〈0.01).It indicated that SHENFU Injection could stimulate the function of adrenal cortex and improve the level of glucocorticoid in AECOPD patients.4.The treated group's cellular immune function was improved significantly after treating(p〈0.05).But there was no change in controlled group(p〉0.05).It indicated that SHENFU Injection could improve the cellular immune function of AECOPD patients.5.There were no significant differences in the curative effect between the cold syndrome type and the heat syndrome type(p〉0.05),which indicated that it was the same effective of SHENFU Injection in the two syndrome types.6.There was no serious adverse effects in both groups,which indicated that it was safe in conventional therapy of westem medicine cooperated with SHENFU Injection.Conclusions:1.The therapeutic efficacy of conventional therapy of westem medicine cooperated with SHENFU Injection in treating AECOPD is superior to conventional therapy of western medicine.2.The SHENFU Injection's improving AECOPD patients' level of glucocorticoid and cellular immune function maybe part of the mechanisms of treating AECOPD.3.There were no significant differences of clinical efficacy and adverse effects between the cold syndrome type and the heat syndrome type.The patients can endure the SHENFU Injection.It indicates that the SHENFU Injection is applicable to the cold and heat syndrome type of AECOPD patients.4.The Warming yang reinforcing qi Method maybe one of the treatments of AECOPD,it worth to further research.