Treating Mechanism Of Jiawei Xiaoyao Pulvis To Treat Acute Psychological Stress-induced Insomnia From The Variety Of Neurotransmitter, Sentiment And Sleep Condition

In the research we using the classical prescription Xiaoyaosan coordinatewith Suanzaoren (semen Ziziphi Spinosae) and Fushen (Poria cum Radix Pini) (Modified Xiaoyaosan)to treat acute psychological stress-induced insomnia. Based on the previous work and other scholar's study and using scientific and objective observation of the modern means, we further evaluated the efficacy of the prescription systematically from neurotransmitter changes of the psychological stress and subjective appraisal of the situation of sleep and sentiment, and investigate the treating mechanism of the rescription preliminarily.Objective: This study uses randomized controlled clinical trial program, to discuss the objective efficacy and mechanism of Modified Xiaoyaosan treating acute psychological stress-induced insomnia.Methods: There were 50 patients included with the standard of acute psychological stress-induced insomnia by May 15, 2007, who were randomly divided into traditional Chinese medicine (Herb Group, H), Western (Western Group, W), Western and Chinese medicine (Integrated Group I), the control group (Control Group, C). H group to take the Modified Xiaoyaosan soups everynight orally, W group to take Estazolam lmg qn bedside Modified Xiaoyaosan placebo orally, I group to tie Modified Xiaoyaosan soups with estazolam lmg qn orally, C group to take Modified Xiaoyaosan placebo orally. Before treatment to relevant measurement of psychologic, sleep, emotional and testing the blood, urine related neurotransmitter, After six weeks of medication review those projects, and clinical efficacy assessed scale (CGI) comprehensive evaluation. After the test was over, using SPSS software to establish a database for statistical analysis, clearly defining a final result.Results: The general information of patients including gender, age, duration of disease, and the PSQI score before treatment was compared to be comparability by statistical analysis. After treatment PSQI score has been markedly improved. The total efficiency of H group is 80% and the W group is 40%, the C group is 77.8%, but the difference between groups was statistically significant. After the treatment all of the groups have improved significantly in SDS, SAS standard scores, the improvement effect of Chinese medicine was better than other groups in all Scale score. The observed indicators of blood before and after treatment were compared: the Chinese Medicine increased serotonin and 5-HIAA levels significantly, decreased beta-endorphin levels. Between the four groups, the group H decreased dopamine, norepinephrine levels the most. But thedifference of the statistics before and after the treatment between groups was not significant, the Statistics results may concerned with the relatively small volume of the samples, it came to the conclusion that Modified Xiaoyaosan improve sleep by neuroendocrine regulated, body stress balanced and immune response.Conclusion: Modified Xiaoyaosan can improve sleep quality, and have similar efficacy with the control drug estazolam, Meanwhile the daytime dysfunction adverse reactions far below estazolam. Meanwhile, the effection of modification to neuroendocrine was significantly better than estazolam.