Effect Of Hemorheology And Clinical Research On Efficacy Of Acute Exacerbations Of Chronic Obstructive Pulmonary Disease (AECOPD) With The Management Of Resolving Phlegm And Promoting Blood Circulation

Chronic obstructive pulmonary disease (COPD) is a disease state characterized by airflow limitation that is not fully reversible. The airflow limitation is usually both progressive and associated with an abnormal inflammatory response of the lungs to noxious particles or gases. The Patients of chronic bronchitis, pulmonary emphysema whose spirometry show airflow limitation not fully reversible can be diagnosed as COPD. These patients of COPD usually have chronic cough, sputum production, air hunger or dyspnea, asthma and chest distress. The medicine workers pay more and more attention to COPD which owe to a great deal of COPD patients, high case fatality rate and weighty economy burden. This article summarize the recordation about COPD in the archaic Chinese medicine literature, the progress of modern Chinese medicine in the study on COPD, the canonical prevention and cure for COPD, progress of modern medicine in the study on COPD, the connection between hemorheology and COPD, and so on. On the basis of the above summarization, we probe into the curative effect on AECOPD of resolving phlegm and promoting blood circulation in this antitheses, prospective study so as to provide scientific evidence for treating COPD with the management resolving phlegm and promoting blood circulation.OBJECTIVEThe aim of the study was to assess the effect of resolving phlegm and promoting blood circulation on clinical symptoms and sign, blood gas analysis, hemorheology with AECOPD patients.METHODSixty hospitalized AECOPD patients (stageâ… -â…¢) with accumulation of phlegm and blood stasis syndrome in the lung in TCM are randomly divided into two groups, the trial group and the control group. The patients of trial group take the Chinese medicine decoctions which have the efficacy of resolving phlegm and promoting blood circulation (Decoction of three kinds of seeds for aged plus others), and simultaneously accept conventional therapy of the western medicine same as the control group (controllability oxygen treatment, bronchodilators, antibiotic, expectorants). The period of treatment is 10 days. To compare the result of two groups by analyzing clinical symptom and sign, blood gas analysis, hemorheology.RESULTS1. Clinical symptom and sign: After the treatment, melioration of clinical symptom and sign in both groups have significant difference. Compared with the control group, melioration of the trial group, such as cough, phlegm, dyspnea, chest distress, rhonchus, appetite is greater, showing significant difference. The above result show that therapy of two groups both can help AECOPD, and the trial group is better than the control group.2. Blood gas analysis: PaO₂ and PaCO₂ of each group have significant difference (P＜0.05) after 10-day treatment compared with pre-treatment that showed both managements of the two groups could improve PaO₂ and reduce PaCO₂. PaCO₂ of the treating group have significant difference (P＜0.05) after 10-day treatment compared with the control group that showed the management of the treating group was better than the control group in PaCO₂. PH of two groups have no significant difference (P＞0.05) whether before or after 10-day.3. hemorheology: Blood viscosity, hematocrit, erythrocyte sedimentation rate (ESR), plasma viscosity, Arbe, index K of treating group have significant difference (P＜0.05 or P＜0.01) after 10-day treatment compared with pre-treatment. Blood viscosity, hematocrit, plasma viscosity of control group also have significant difference (P＜0.01) after 10-day treatment compared with pre-treatment. And Blood viscosity (high shear stress rate), hematocrit, erythrocyte sedimentation rate (ESR), Arbe, index K improve more greatly in the treating group (P＜0.05).CONCLUSIONSThe management of resolving phlegm and promoting blood circulation could improve the clinical symptoms and sign, remedy the state of anoxia and carbon dioxide retention, hemorheology so as to accelerate rehabilitation of AECOPD patients.