The Impacts Of Chronic Mycoplasma Pneumoniae Or Chlamydia Pneumoniae Infection On Asthma In Children

Asthma is a serious global health problem. People of all ages in countries throughout the world are affected by this chronic airway disorder that, when uncontrolled, can place severe limits on daily life and is sometimes fatal. The prevalence of asthma is increasing in most countries, especially among children, and the asthma has been becoming one of the most important research subject in the world. It is generally accepted that out of asthma attacks or asthma exacerbations with respiratory tract infections, about 30 percents of patients are associated with mycoplasma pneumoniae or chlamydia pneumoniae infections. This paper used the Enzyme-linked Immunosorbent Assay and the Polymerase Chain Reaction and detected the serue IgM antibody and the throat swab DNA of MP or CP in children with asthma in order to confirm the impacts of chronic or persistant MP or CP infections on bronchial asthma and bronchopneumonia at the same time. In this group we detected MP and CP specific DNA and IgM in 58 asthma attack children, 30 pneumonia children and 30 healthy children who had not recent respiratory infections for case control. Allcases were collected sera 1ml to detect IgM antibody and the throat swab sample when admitted. If the specific DNA or IgM detected with PCR or ELISA, continous treatment with macrolide antibiotics was followed and redected with PCR after 14 days,21 days. The positive rate of specific MP/CP IgM in asthma patients (17.64%,10/58;12.07%, 7/58) was higher than that of healthy control group (0.00%/0.00%, P<0.05), however the rate was not significantly different from pneumonia patients (16.67%,5/30;10.0%, 3/30) (P>0.05). Chronic infection rates of MP/CP in asthma patients (10.34%,6/58;6.90%,4/58) was higher than that of pneumonia patients group (3.33%,1/30;0.00%,0/30) (P<0.05). Other pathogens were identified in 3 of 7 (42.9%) asthma patients with CP. Anti-MP/CP treatment is effective in these MP/CP infections asthma chindren. MP/CP infections, especially the chronic infection that has a close relationship with the asthma, although the relationship between the MP/CP infection and the asthma attacking is still need to be deeply studied. After all elucidate the impacts of MP/CP infections on the pathogenesis of asthma in children have important significance in establishing guidline of treatment of the disease, cutting down the clinic symptom anddecreasing the morbidity of the children to develop the asthma. Active and effective treatment MP/CP infection may control the episode of the asthma and relieve the asthma at the earliest opportunity.Fluorescent quantitation PCR possess high accurasy in pathogen confirmation of respiratory tract MP/CP infection, it is a quick aetiology detection technique that have wide clinical application walue.