The Relation Among Serum Fibrinogen, Lipoprotein(a), Uric Acid, Two Hour Blood Glucose And The Extent Of Coronary Stenosis

BACKGROUND: Since smoking, age, hypertension, hyperlipemia and diabetes mellitus have been validated as risk factors of CHD, it is reported that fibrinogen, lipoprotein(a),uric acid, two hour blood glucose are also related to CHD. But the problem whether these markers relate to the extent of coronary stenosis, especially which one is most related to it has not been solved so far. The study explores the relationship between these markers and the extent of coronary stenosis by using coronary angiography and measuring the serum Fg, Lp(a), UA and 2hBG. In addition, the study also shows the intensity of the dependability by multivariate regression analysis,METHODS: In the study 112 patients with CHD were selected in the department of cardiology in Shandong provincial hospital from January 2006 to January 2007. After admission all candidates underwent coronary angiography and their serum Fg, Lp(a), UA and 2hBG were determined. According to the result of coronary angiography all the subjects were divided into 4 groups: normal control group (stenosis < 50%), single-vessel (LM or LAD or LCX or RCA) group, double-vessel group, triple-vessel group and tetra-vessel group. Their coronary stenosis score were accumulated based on the extent of coronary stenosis.RESULTS: 1. There was significant difference in the levels of Fg, Lp(a), UA and 2hBG among these groups, and the levels of them in normal control, single-, double-, triple-and tetra-vessel groups increased by degrees. 2.We found a linear correlation between Fg, Lp(a), UA, 2hBG and CSS respectively. 3.The multivariate regression analysis showed that the correlated intensity of these markers were Lp(a), Fg, 2hBGand UA one by one.CONCLUSIONS: The levels of Fg, Lp(a), UA and 2hBG are related to the severity ofthe coronary artery lesions.