Clinical Analysis Of Extra-pulmonary Complications In Children With Mycoplasma Pneumoniae Infection And High-risk Factors

Objective: To understand the clinical features, therapeutic effect and prognosis of extra-pulmonary infections by Mycoplasma pneumoniae(MP) and their high-risk factors. Methods: ELISA was used to detect anti-MP IgM, PCR was used to detect MP-DNA. Either MP-IgM positive or MP-DNA positive is defined as MP-positive cases in this study. 344 such cases were analyzed retrospectively. Results: All 344 cases have respiratory infections and 182 cases (52.9%) suffered from extra-pulmonary complications. Of these complications, 30.8%, 28.0% and 22.0% were found in digestive, cardiovascular and hematological system respectively. All of these cases were improved after treatment with macrolides antibiotics for about 2 weeks, except one case need ciprofloxacin for 9 days in addition. There are statistic differentiation in the existence of fever, persistence of fever and the starting time of macrolide between the cases infected by MP in respiratory tract only and the cases infected by MP with extra—pulmonary complication(p<0.05): the latter are usually more incidental to show the manifestation of persistent fever and found to be treated with macrolide later. There are no statistic differentiation in age, gender, CRP, ESRand the course of disease between the two groups. Conclusion: The incidence of extra-pulmonary complications in children with mycoplasma pneumoniae infection is high, and almost all systems of the body could be involved. Persistent fever may be an important correlative factor of extra—pulmonary complications caused by MP, and early therapy of macrolide can reduce the extra—pulmonary complications.